Inosine - a Multifunctional Treatment for Complications of Neurologic Injury.
Inosine - a Multifunctional Treatment for Complications of Neurologic Injury.
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DOI：
10.1159/000493831
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Adam RM
中科院分区：
文献类型：
--
作者：
Doyle C;Cristofaro V;Sullivan MP;Adam RM
由创伤或疾病引起的脊髓损伤 (SCI) 会导致运动和感觉异常，具体取决于损伤的程度、严重程度和持续时间。 SCI 最明显的后果是影响下肢和上肢的瘫痪。 SCI 还会导致膀胱和肠道控制丧失，这两者都会对受影响个体的社会、心理、功能、医疗和经济福祉产生有害的终生影响。目前，脊髓损伤既没有治愈方法，也没有对其后果进行适当的管理。尽管药物可以缓解 SCI 并发症（包括肌肉痉挛、下尿路功能障碍和肠反射亢进）的症状，但修复脊髓损伤和恢复正常肢体和器官功能的策略仍有待实现。在这篇综述中，我们讨论了支持使用天然存在的嘌呤核苷肌苷来改善 SCI 破坏性后遗症的实验证据。有证据表明肌苷是一种安全的新型药物，具有多功能特性，可有效治疗 SCI 和其他神经病的并发症。
Spinal cord injury (SCI) caused by trauma or disease leads to motor and sensory abnormalities that depend on the level, severity and duration of the lesion. The most obvious consequence of SCI is paralysis affecting lower and upper limbs. SCI also leads to loss of bladder and bowel control, both of which have a deleterious, life-long impact on the social, psychological, functional, medical and economic well being of affected individuals. Currently, there is neither a cure for SCI nor is there adequate management of its consequences. Although medications provide symptomatic relief for the complications of SCI including muscle spasms, lower urinary tract dysfunction and hyperreflexic bowel, strategies for repair of spinal injuries and recovery of normal limb and organ function are still to be realized. In this review, we discuss experimental evidence supporting the use of the naturally occurring purine nucleoside inosine to improve the devastating sequelae of SCI. Evidence suggests inosine is a safe, novel agent with multifunctional properties that is effective in treating complications of SCI and other neuropathies.
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影响因子：
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作者：
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通讯作者：
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