Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo.
Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo.
复制标题
DOI：
10.1038/bjc.1996.11
复制
发表时间：
1996-01
影响因子：
8.8
通讯作者：
Evelhoch, JL
中科院分区：
文献类型：
--
作者：
Zhao, M;Pipe, JG;Bonnett, J;Evelhoch, JL
核磁共振非侵入性测量水的表观扩散系数(ADC)，它对组织的生物物理特性很敏感。因为抗癌治疗会改变肿瘤的病理生理学，所以治疗可能会改变肿瘤的ADC值。为了验证这一假设，在南卡罗来纳州测量了ADC。在环磷酰胺治疗前和治疗后9天内接种小鼠RIF-1肿瘤。环磷酰胺治疗后，肿瘤的ADC值呈剂量依赖性、可逆性增加，这与治疗诱导的细胞死亡导致的间质水的增加是一致的。由于肿瘤水的ADC在肿瘤体积不变的情况下显著增加，因此它的测量可能为早期检测抗癌治疗的反应提供一种新的手段。如果在本研究中观察到的ADC值的变化在不同肿瘤类型的常用抗癌治疗中是明显的，并且具有治疗反应的特异性，该方法可以广泛适用于作为反应预测指标，因为磁共振成像可以用于测量人类肿瘤的ADC值。
Nuclear magnetic resonance (NMR) non-invasively measures the apparent diffusion coefficient (ADC) of water, which is sensitive to the biophysical characteristics of tissue. Because anti-cancer treatment alters tumour pathophysiology, tumour ADC may be altered by treatment. In order to test this hypothesis, ADC was measured in s.c. implanted murine RIF-1 tumours before and up to 9 days after treatment with cyclophosphamide. A dose-dependent, reversible increase in tumour ADC was observed after cyclophosphamide treatment, which is consistent with an increase in the fraction of interstitial water due to treatment-induced cell death. Because tumour water ADC is increased substantially at a time when there is no change in tumour volume for a dose which produces minimal cell kill, its measurement could provide a novel means for early detection of response to anti-cancer therapy. If the changes in ADC observed in the present study are evident for commonly used anti-cancer therapies in different tumour types and specific to a therapeutic response, the approach could be broadly applicable as a response predictor since magnetic resonance imaging can be used to measure ADC in human tumours.
登录
查看更多内容
影响因子：
45.3
作者：
WAHL, RL;ZASADNY, K;CODY, R
通讯作者：
CODY, R
影响因子：
2.5
作者：
BRAUNSCHWEIGER P G;SCHIFFER L;FURMANSKI P
通讯作者：
FURMANSKI P
影响因子：
2.2
作者：
MERBOLDT, KD;HANICKE, W;FRAHM, J
通讯作者：
FRAHM, J
影响因子：
19.7
作者：
SOSTMAN, HD;PRESCOTT, DM;CHARLES, HC
通讯作者：
CHARLES, HC
影响因子：
4.4
作者：
TANNER, JE
通讯作者：
TANNER, JE