First comprehensive analysis of Aedes aegypti bionomics during an arbovirus outbreak in west Africa: Dengue in Ouagadougou, Burkina Faso, 2016-2017.
First comprehensive analysis of Aedes aegypti bionomics during an arbovirus outbreak in west Africa: Dengue in Ouagadougou, Burkina Faso, 2016-2017.
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西非虫媒病毒爆发期间埃及伊蚊生物学的首次综合分析：布基纳法索瓦加杜古的登革热，2016-2017年。
DOI：
10.1371/journal.pntd.0010059
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发表时间：
2022-07
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
登革热在西非的出现以2016年和2017年布基纳法索的疫情为典型，这是该国迄今为止最大的疫情。在这两年，我们在疫情集中的首都瓦加杜古或附近对伊蚊种群进行了为期三个月的调查。在1200LG（城市）、Tabtenga（近郊）和Goundry（农村）地区，我们收集了室内和室外休息的成蚊，对幼虫栖息地和产蛹容器进行了特征描述，并在实验室中将未成熟阶段饲养到成虫阶段进行鉴定。所有成蚊均进行形态鉴定。采用聚合酶链反应（PCR）鉴定宿主物种（取血食）。采用广义混合模型研究成虫或幼虫密度与多个解释变量之间的关系。从1780间房屋样本中，发现成伊蚊；在这两年中，两个城市地点（Tabtenga和1200 LG）的埃及伊蚊数量明显多于农村地点（Goundry），而农村地点（Goundry）的按蚊数量要多得多。成虫采集结果显示，病媒生物具有高度的亲外性和亲人性（约占90%），但在室内捕获的吸血雌蚊所占比例相对较高。产蛹最多的生境是废轮胎（占总蛹的37%）、动物食槽（44%）和大水桶（30%）。虽然隐蚊指数不是成蚊丰度的可靠指标，但降雨和容器水位、采集月份和容器类型/用途等因素对成蚊和未成熟期密度有共同影响。空间分析显示密度自相关，成虫期和未成熟期热点存在部分重叠。结果为选择适当的病媒控制方法提供了证据基础，以尽量减少瓦加杜古未来暴发的风险、频率和规模。提出了一项综合战略，将社区驱动的做法、废物处理和基于杀虫剂的干预措施结合起来。讨论了在西非或整个非洲制定虫媒病毒控制区域方法的前景。埃及伊蚊是黄热病、基孔肯雅登革热和寨卡病毒等人类疾病最有效的传播媒介。西非是登革热的新兴热点，布基纳法索2016年和2017年的疫情就说明了这一点。巧合的是，本研究对伊蚊的生物学和行为进行了研究。2016年8月至2017年10月在瓦加杜古城市、城郊和农村地区发现埃及伊蚊。来自1700多个家庭的结果显示，Ae。埃及伊蚊优先以人类为食，主要在户外休息。最常见的蛹生产栖息地是废弃的车辆轮胎、动物水槽和大水桶。城市和城郊地区的侵染率较高。一系列以社区为基础的控制措施适合在病媒控制规划中加以考虑，以预防疫情。这项研究提供了当代最完整的伊蚊描述。这为预防或减轻疾病爆发的蚊虫控制项目提供了证据。简要讨论了西非地区病媒控制规划的潜力。
Dengue’s emergence in West Africa was typified by the Burkina Faso outbreaks in 2016 and 2017, the nation’s largest to date. In both years, we undertook three-month surveys of Aedes populations in or near the capital city Ouagadougou, where the outbreaks were centered. In 1200LG (urban), Tabtenga (peri-urban) and Goundry (rural) localities, we collected indoor and outdoor resting mosquito adults, characterized larval habitats and containers producing pupae and reared immature stages to adulthood in the laboratory for identification. All mosquito adults were identified morphologically. Host species (from which bloodmeals were taken) were identified by PCR. Generalized mixed models were used to investigate relationships between adult or larval densities and multiple explanatory variables. From samples in 1,780 houses, adult Ae. aegypti were significantly more abundant in the two urban localities (Tabtenga and 1200 LG) in both years than in the rural site (Goundry), where Anopheles spp. were far more common. Results from adult collections indicated a highly exophilic and anthropophilic (>90% bloodmeals of human origin) vector population, but with a relatively high proportion of bloodfed females caught inside houses. Habitats producing most pupae were waste tires (37% of total pupae), animal troughs (44%) and large water barrels (30%). While Stegomyia indices were not reliable indicators of adult mosquito abundance, shared influences on adult and immature stage densities included rainfall and container water level, collection month and container type/purpose. Spatial analysis showed autocorrelation of densities, with a partial overlap in adult and immature stage hotspots. Results provide an evidence base for the selection of appropriate vector control methods to minimize the risk, frequency and magnitude of future outbreaks in Ouagadougou. An integrated strategy combining community-driven practices, waste disposal and insecticide-based interventions is proposed. The prospects for developing a regional approach to arbovirus control in West Africa or across Africa are discussed. Aedes aegypti is the most efficient vector of human diseases including yellow fever, dengue chikungunya and Zika. West Africa is an emerging hotspot for dengue, as illustrated by Burkina Faso’s outbreaks in 2016 and 2017. Coincidentally, this study investigated the bionomics and behavior of Ae. aegypti in urban, peri-urban and rural localities of Ouagadougou, from August to October in 2016 and 2017. The results from over 1700 homes showed that Ae. aegypti preferentially fed on humans and rested primarily outdoors. The most common pupal productive habitats were discarded vehicle tires, animal water troughs and large water barrels. Infestation rates were higher in the urban and peri-urban localities. A range of community-based control measures are suitable for consideration in a vector control program to prevent outbreaks. This study provides the most complete contemporary description of an Ae. aegypti population in West Africa, providing evidence for mosquito control programs to prevent or mitigate disease outbreaks. The potential of a regional vector control program for west Africa is discussed briefly.
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影响因子：
56.9
作者：
Aubry, Fabien;Dabo, Stephanie;Lambrechts, Louis
通讯作者：
Lambrechts, Louis
影响因子：
3.8
作者：
Abilio, Ana Paula;Abudasse, Gastao;Gudo, Eduardo Samo
通讯作者：
Gudo, Eduardo Samo
影响因子：
16.6
作者：
Aubry F;Jacobs S;Darmuzey M;Lequime S;Delang L;Fontaine A;Jupatanakul N;Miot EF;Dabo S;Manet C;Montagutelli X;Baidaliuk A;Gámbaro F;Simon-Lorière E;Gilsoul M;Romero-Vivas CM;Cao-Lormeau VM;Jarman RG;Diagne CT;Faye O;Faye O;Sall AA;Neyts J;Nguyen L;Kaptein SJF;Lambrechts L
通讯作者：
Lambrechts L
DOI：
10.2471/blt.09.067892
发表时间：
2010-03-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Arunachalam, Natarajan;Tana, Susilowati;Petzold, Max
通讯作者：
Petzold, Max
影响因子：
3.3
作者：
Abe, M;McCall, PJ;Kroeger, A
通讯作者：
Kroeger, A