Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART.
Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART.
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DOI：
10.1007/s13365-014-0246-6
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发表时间：
2014-06
影响因子：
3.2
通讯作者：
Navia, B. A.
中科院分区：
文献类型：
--
作者：
Harezlak, J.;Cohen, R.;Gongvatana, A.;Taylor, M.;Buchthal, S.;Schifitto, G.;Zhong, J.;Daar, E. S.;Alger, J. R.;Brown, M.;Singer, E. J.;Campbell, T. B.;McMahon, D.;So, Y. T.;Yiannoutsos, C. T.;Navia, B. A.
The reasons for persistent brain dysfunction in chronically HIV-infected persons on stable combined antiretroviral therapies (CART) remain unclear. Host and viral factors along with their interactions were examined in 260 HIV-infected subjects who underwent magnetic resonance spectroscopy (MRS) Metabolite concentrations (NAA/Cr, Cho/Cr, MI/Cr and Glx/Cr) were measured in the basal ganglia, the frontal white matter and grey matter and the best predictive models were selected using a bootstrap-enhanced Akaike Information Criterion (AIC). Depending on the metabolite and brain region, age, race, HIV RNA concentration, ADC stage, duration of HIV infection, nadir CD4, and/or their interactions were predictive of metabolite concentrations, particularly the basal ganglia NAA/Cr and the mid-frontal NAA/Cr and Glx/Cr whereas current CD4 and the CPE index rarely or did not predict these changes. These results show for the first time that host and viral factors related to both current and past HIV status contribute to persisting cerebral metabolite abnormalities and provide a framework for further understanding neurological injury in the setting of chronic and stable disease.
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影响因子：
11.2
作者：
Ernst, Thomas;Yakupov, Renat;Nakama, Helenna;Crocket, Grace;Cole, Michael;Watters, Michael;Ricardo-Dukelow, Mary Lynn;Chang, Linda
通讯作者：
Chang, Linda
影响因子：
3.2
作者：
Ances BM;Bhatt A;Vaida F;Rosario D;Alexander T;Marquie-Beck J;Ellis RJ;Letendre S;Grant I;McCutchan JA;HIV Neurobehavioral Research Center (HNRC) Group
通讯作者：
HIV Neurobehavioral Research Center (HNRC) Group
DOI：
10.1073/pnas.96.14.8212
发表时间：
1999-07-06
影响因子：
11.1
作者：
Kaul, M;Lipton, SA
通讯作者：
Lipton, SA
影响因子：
1.8
作者：
Austin, PC;Tu, JV
通讯作者：
Tu, JV
影响因子：
11.2
作者：
Ellis, RJ;Hsia, K;Dupont, R
通讯作者：
Dupont, R