Examination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions.
Examination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions.
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DOI:
10.1038/s41598-023-27401-0
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发表时间:
2023-01-13
影响因子:
4.6
通讯作者:
中科院分区:
文献类型:
--
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Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteoarchaeological material are a frequent finding in archaeological contexts and have the potential to offer information about previous human populations, which can be illuminating about our current condition. Using a set of samples comprising different skeletal elements and bone structures, here we explore for the first time the possibility of extracting metabolites from osteoarchaeological material. Here, a protocol for extraction and measurement of extracted polar and less-polar/apolar metabolites by ultra-high performance liquid chromatography hyphenated to high resolution mass spectrometry is presented to measure the molecules separated after a reversed phase and hydrophilic interaction liquid chromatography column. Molecular information was obtained, showing that osteoarchaeological material is a viable source of molecular information for metabolomic studies.
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影响因子:
4.1
作者:
Fan J;Jahed V;Klavins K
通讯作者:
Klavins K
影响因子:
6.1
作者:
Chetwynd, Andrew J.;David, Arthur
通讯作者:
David, Arthur
影响因子:
2.8
作者:
Bertrand, Benoit;Cunha, Eugenia;Hedouin, Valery
通讯作者:
Hedouin, Valery
影响因子:
5.9
作者:
Bellissimo MP;Roberts JL;Jones DP;Liu KH;Taibl KR;Uppal K;Weitzmann MN;Pacifici R;Drissi H;Ziegler TR;Alvarez JA
通讯作者:
Alvarez JA
影响因子:
7.4
作者:
Adav SS;Wang Y
通讯作者:
Wang Y