The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun.
The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun.
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DOI：
10.1016/j.virol.2020.07.013
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发表时间：
2020-10
期刊：
影响因子：
3.7
通讯作者：
Lemasson I
中科院分区：
文献类型：
--
作者：
Polakowski N;Pearce M;Kuguyo O;Boateng G;Hoang K;Lemasson I
HBZ is expressed by the complex retrovirus, Human T-cell Leukemia Virus type 1, and implicated in pathological effects associated with viral infection. From the nucleus, HBZ alters gene expression by interacting with a variety of transcriptional regulatory proteins, among which is c-Jun. Previously, one of the three HBZ variants, HBZUS, was reported to decrease c-Jun expression by promoting its degradation. Here we show that another variant, HBZS1, produces the opposite effect. In the presence of HBZS1, c-Jun expression increases due to its stabilization. Our data suggest that this effect requires the ability of HBZS1 to interact with c-Jun. We provide evidence that HBZS1 inhibits the proteosomal degradation of c-Jun initiated by the Cop1-containing ubiquitin ligase complex. HBZS1 is the most abundant variant in HTLV-1-infected T-cells, and our data indicate that levels of c-Jun expression in infected cells are consistent with effects of HBZS1.
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影响因子：
64.8
作者：
LAMPH, WW;WAMSLEY, P;VERMA, IM
通讯作者：
VERMA, IM
影响因子：
4.8
作者：
Basbous, J;Arpin, C;Mesnard, JM
通讯作者：
Mesnard, JM
影响因子：
5.4
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Murata, K;Hayashibara, T;Kamihira, S
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Kamihira, S
影响因子：
4.8
作者：
Kardassis, D;Papakosta, P;Moustakas, A
通讯作者：
Moustakas, A
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影响因子：
5.2
作者：
Gazon H;Barbeau B;Mesnard JM;Peloponese JM Jr
通讯作者：
Peloponese JM Jr