The electrocardiographic forward problem: A benchmark study.
The electrocardiographic forward problem: A benchmark study.
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DOI：
10.1016/j.compbiomed.2021.104476
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发表时间：
2021-07
影响因子：
7.7
通讯作者：
MacLeod RS
中科院分区：
文献类型：
--
作者：
Bergquist JA;Good WW;Zenger B;Tate JD;Rupp LC;MacLeod RS
心电正问题是无创心电成像(ECGI)的重要组成部分，ECGI根据心源测量计算躯干电位。正问题几乎没有误差来源，因为它们在物理上是合适的，并且得到了成熟的数值和计算技术的支持。然而，正演计算和测量的躯干信号之间的实验验证研究报告的残余误差仍然令人惊讶地高。为了检验这样一种假设，即不完整的心源采样，特别是房室平面以上的采样是正解误差的主要贡献因素。我们使用了悬浮在人形电解躯干槽中的改良的朗宁多夫制剂和一种新型的心包笼记录阵列来彻底采集心脏电位。通过这种精心控制的实验准备，我们最大限度地减少了可能的误差来源，包括几何误差和躯干不均匀。我们逐步去除房室平面上方的记录信号，以确定不完全来源采样对正向计算的躯干-坦克电位的影响。在两个实验中，我们研究了三种不同的起搏序列类型(窦性起搏、左心室后壁起搏和前壁起搏)总共记录到的240次心搏。在笼形电极完全采样的情况下，躯干-坦克电位计算值与实测值之间的相关系数均在0.93以上(最大值为0.99)。所有节拍类型的平均均方根误差也很低，小于或等于0.10 mV。当我们只包括房室平面以下的笼子测量时，我们观察到正解精度急剧下降。首先，我们使用完整的心源测量进行正向计算的电势为类似的研究设定了基准。其次，这项研究证实了在房室平面上进行完整的心源采样以产生准确的正演计算躯干电位的重要性。使用这些更完整和高精度的数据集测试ECGI系统和技术将改进反向技术和心脏电异常的非侵入性检测。
Electrocardiographic forward problems are crucial components for noninvasive electrocardiographic imaging (ECGI) that compute torso potentials from cardiac source measurements. Forward problems have few sources of error as they are physically well posed and supported by mature numerical and computational techniques. However, the residual errors reported from experimental validation studies between forward computed and measured torso signals remain surprisingly high. To test the hypothesis that incomplete cardiac source sampling, especially above the atrioventricular (AV) plane is a major contributor to forward solution errors. We used a modified Langendorff preparation suspended in a human-shaped electrolytic torso-tank and a novel pericardiac-cage recording array to thoroughly sample the cardiac potentials. With this carefully controlled experimental preparation, we minimized possible sources of error, including geometric error and torso inhomogeneities. We progressively removed recorded signals from above the atrioventricular plane to determine how the forward-computed torso-tank potentials were affected by incomplete source sampling. We studied 240 beats total recorded from three different activation sequence types (sinus, and posterior and anterior left-ventricular free-wall pacing) in each of two experiments. With complete sampling by the cage electrodes, all correlation metrics between computed and measured torso-tank potentials were above 0.93 (maximum 0.99). The mean root-mean-squared error across all beat types was also low, less than or equal to 0.10 mV. A precipitous drop in forward solution accuracy was observed when we included only cage measurements below the AV plane. First, our forward computed potentials using complete cardiac source measurements set a benchmark for similar studies. Second, this study validates the importance of complete cardiac source sampling above the AV plane to produce accurate forward computed torso potentials. Testing ECGI systems and techniques with these more complete and highly accurate datasets will improve inverse techniques and noninvasive detection of cardiac electrical abnormalities.
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影响因子：
8.4
作者：
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通讯作者：
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