Magnetic Nanotubes Influence the Response of Dorsal Root Ganglion Neurons to Alternating Magnetic Fields
Magnetic Nanotubes Influence the Response of Dorsal Root Ganglion Neurons to Alternating Magnetic Fields
复制标题
磁性纳米管影响背根神经节神经元对交变磁场的反应
DOI：
10.1115/1.4004305
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
M. Srivatsan
中科院分区：
文献类型：
--
作者：
Jining Xie;Linfeng Chen;V. Varadan;Sahitya Chetan;M. Srivatsan
磁性纳米管具有神经科学应用的潜力，因为控制磁性纳米管的方向或运动的可行性以及它们通过外部磁场递送化学物质或生物分子的能力，这可以促进神经突的定向生长。因此，我们试图研究层粘连蛋白处理的磁性纳米管和外部交变磁场对细胞培养的背根神经节（DRG）神经元生长的影响。采用水热法合成了磁性纳米管，并对其进行了表征，以确定其中空结构、赤铁矿和磁赤铁矿相以及磁性。背根神经节神经元培养层粘连蛋白耦合的磁性纳米管的存在下，交变磁场。电子显微镜显示磁性纳米管与生长的神经突之间存在密切的相互作用。相差显微镜显示活生长的神经元，这表明磁性纳米管和交变磁场的存在下的组合是耐受的DRG神经元。层粘连蛋白处理的磁性纳米管和施加的磁场对DRG神经元的存活、生长和电活动的协同效应目前正在研究中。
Magnetic nanotubes hold the potential for neuroscience applications because of the feasibility of controlling the orientation or movement of magnetic nanotubes and their ability to deliver chemicals or biomolecules by an external magnetic field, which can facilitate directed growth of neurites. Therefore, we sought to investigate the effects of laminin treated magnetic nanotubes and external alternating magnetic fields on the growth of dorsal root ganglion (DRG) neurons in cell culture. Magnetic nanotubes were synthesized by a hydrothermal method and characterized to confirm their hollow structure, the hematite and maghemite phases, and the magnetic properties. DRG neurons were cultured in the presence of laminin coupled magnetic nanotubes under alternating magnetic fields. Electron microscopy showed a close interaction between magnetic nanotubes and the growing neurites. Phase contrast microscopy revealed live growing neurons suggesting that the combination of the presence of magnetic nanotubes and the alternating magnetic field were tolerated by DRG neurons. The synergistic effects, from both laminin treated magnetic nanotubes and the applied magnetic field on the survival, growth, and electrical activities of the DRG neurons, are currently being investigated.
丝状伪足和放射状肌动蛋白束穿过神经元生长锥的横向运动机制。
影响因子：
3.4
作者：
Oldenbourg,R;Katoh,K;Danuser,G
通讯作者：
Danuser,G
影响因子：
17.1
作者：
Xie, Jingwei;MacEwan, Matthew R.;Li, Xiaoran;Sakiyama-Elbert, Shelly E.;Xia, Younan
通讯作者：
Xia, Younan
影响因子：
10.8
作者：
Hu, H;Ni, YC;Parpura, V
通讯作者：
Parpura, V