Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice.
Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice.
复制标题
DOI：
10.1002/npr2.12202
复制
发表时间：
2021-12
影响因子：
2.5
通讯作者：
Kasai S
中科院分区：
文献类型：
--
作者：
Sasaki K;Ishikawa T;Ikeda K;Kasai S
丁托啡诺和丁丙诺啡是阿片受体激动-拮抗剂混合药物，广泛用于人和动物的镇痛。关于多种阿片类药物相互作用的报道很少，当它们与其他阿片类药物联合使用时，它们的抗伤害感受作用仍不清楚。因此，我们报告了布托啡诺与丁丙诺啡联合使用对C57BL/6JJcl小鼠的抗伤害感受作用的初步发现。两种药物要么同时给药，要么按不同顺序给药。与基线值相比，甩尾和热板测试潜伏期与给药顺序无关。此外，观察到在丁丙诺啡之后给予丁托啡诺的潜伏期增强。联合使用这些药物可能不会减弱镇痛效果。此外，通过改变这些药物的给药顺序可以增强这些作用。在未来的明确研究中，有必要进一步研究其潜在机制的分子基础。
Butorphanol and buprenorphine are mixed opioid receptor agonist‐antagonist drugs widely used as analgesics in people and animals. There are few reports concerning the interaction of multiple opioids, and their antinociceptive effects, when combined with other opioids, remain unclear. Therefore, we report the preliminary findings of the antinociceptive effects of the combined use of butorphanol and buprenorphine in C57BL/6JJcl mice. Both drugs were administered either simultaneously or in different orders. Compared with the baseline values, the tail‐flick and hot‐plate test latencies increased regardless of the order of administration. Furthermore, enhanced latencies were observed on administration of butorphanol followed by buprenorphine. Combined use of these drugs may not attenuate analgesic efficacy. Besides, enhancement of these effects can be obtained by changing the order of the administration of these drugs. It is necessary to further investigate the molecular basis of the underlying mechanism in future definitive studies.
登录
查看更多内容
影响因子：
4.7
作者：
Ide, Soichiro;Minami, Masabumi;Ikeda, Kazutaka
通讯作者：
Ikeda, Kazutaka
影响因子：
3.1
作者：
Webster, Lynn
通讯作者：
Webster, Lynn
影响因子：
8.8
作者：
Nelson, KE;Eisenach, JC
通讯作者：
Eisenach, JC
影响因子：
2.4
作者：
Abreu, Mariana;Aguado, Delia;Gomez de Segura, Ignacio A.
通讯作者：
Gomez de Segura, Ignacio A.
影响因子：
2.3
作者：
Grinnell, Steven G.;Ansonoff, Michael;Pasternak, Gavril W.
通讯作者：
Pasternak, Gavril W.