Heterotypic control of basement membrane dynamics during branching morphogenesis.
Heterotypic control of basement membrane dynamics during branching morphogenesis.
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DOI：
10.1016/j.ydbio.2014.12.011
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Larsen, Melinda
中科院分区：
文献类型：
--
作者：
Nelson, Deirdre A.;Larsen, Melinda
关键词：
许多哺乳动物器官经历分支形态发生，形成高度树状结构，具有最大的表面积，以实现专门的器官功能。塑造新兴组织结构的细胞与细胞和细胞与基质的协同粘附是由动态基底膜引导的。基底膜的特性由相互作用的上皮细胞和间充质细胞群相互控制。在这里，我们讨论分支形态发生如何需要基底膜重塑来调节形态发生过程中细胞图案化所需的细胞基质和细胞间粘附，以及基底膜如何通过刺激细胞图案化、力产生和力传导来影响形态发生。我们认为，除了创建成熟的上皮结构外，分支形态发生过程中上皮基底膜的重塑对于促进基质间充质的成熟以创建成熟的器官结构也至关重要。发育细胞-基质和细胞-细胞相互作用的概括对于寻求恢复器官功能的组织工程和再生策略至关重要。
Many mammalian organs undergo branching morphogenesis to create highly arborized structures with maximized surface area for specialized organ function. Cooperative cell-cell and cell-matrix adhesions that sculpt the emerging tissue architecture are guided by dynamic basement membranes. Properties of the basement membrane are reciprocally controlled by the interacting epithelial and mesenchymal cell populations. Here we discuss how basement membrane remodeling is required for branching morphogenesis to regulate cell-matrix and cell-cell adhesions that are required for cell patterning during morphogenesis and how basement membrane impacts morphogenesis by stimulation of cell patterning, force generation, and mechanotransduction. We suggest that in addition to creating mature epithelial architecture, remodeling of the epithelial basement membrane during branching morphogenesis is also essential to promote maturation of the stromal mesenchyme to create mature organ structure. Recapitulation of developmental cell-matrix and cell-cell interactions are of critical importance in tissue engineering and regeneration strategies that seek to restore organ function.
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影响因子：
4
作者：
Daley, William P.;Yamada, Kenneth M.
通讯作者：
Yamada, Kenneth M.
影响因子：
2.7
作者：
Daley, William P.;Gulfo, Kathryn M.;Sequeira, Sharon J.;Larsen, Melinda
通讯作者：
Larsen, Melinda
影响因子：
64.5
作者：
Fujiwara H;Ferreira M;Donati G;Marciano DK;Linton JM;Sato Y;Hartner A;Sekiguchi K;Reichardt LF;Watt FM
通讯作者：
Watt FM
影响因子：
2.5
作者：
Daley, William P.;Kohn, Joshua M.;Larsen, Melinda
通讯作者：
Larsen, Melinda
影响因子：
4.3
作者：
Cox TR;Erler JT
通讯作者：
Erler JT