Papovaviral persistent infections.
Papovaviral persistent infections.
复制标题
乳多空病毒持续感染。
DOI：
10.1128/mr.46.4.384-425.1982
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Norkin,LC
中科院分区：
文献类型：
--
作者：
Norkin,LC
Variety of Host Responses to Virus Infection Virologists concerned with the pathogenesis of infection have long been preoccupied with acute self-limited diseases such as measles and poliomyelitis. In such cases, overt symptoms generally appear within several days to several weeks after infection. Subsequently, if the dis-ease is not fatal, the infectiousagent is generally eliminated from the host, which is then immune to reinfection. It is now recognized that viral infection may lead to host responses other than acute illness. In particular, persistent virus infections have become a subject of increasing attention as both their frequency and medical importance have become apparent. Virus infections may also be asymptomatic. In other instances, infection may lead to neoplasia. It is noteworthy that papova-virus infections may give rise to each of the host responses noted above. Persistent virus infections may be of several types. In one variety, characteristic of infections with herpesviruses, the virus becomes latent after what appears to be a typical acute primary infection. Subsequently, there are intermittent episodes of disease between which virus is usu-ally not demonstrable. Another type of persis-tent infection, termed slow (slow referring to the disease course, not the virus), is characterized by prolonged periods of infection (often years) before symptoms appear. The disease process then develops over a protracted period, eventu-ally resulting in death. These categories of per-sistent infection are not strictly alternatives. As seen below, papovavirus infections may display characteristics of each type.The Papovaviruses The papovaviruses, in particular simian virus 40 (SV40) and polyoma virus of mice, have attracted great interest primarily because of their capacity to induce neoplastic transforma-tions of some mammalian cells both in vitro and in vivo (see reference 282 for a review). Viral genes persist in transformed cells, and in at least some instances, viral gene products are continuously needed to maintain the transformed cell phenotype. Therefore, these viruses have been extensively studied with the aim of explaining the mechanisms by which the normal controls of cell growth and behavior can be altered to result in neoplasia. Furthermore, the small size of the
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多瘤病毒 DNA 在多瘤转化大鼠细胞诱导性 LPT 系中的整合位点
影响因子：
5.4
作者：
E. Mendelsohn;N. Baran;A. Neer;H. Manor
通讯作者：
H. Manor
细胞染色体数目对猿猴病毒40复制的影响。
影响因子：
3.7
作者：
J. Robb;K. Huebner
通讯作者：
K. Huebner
人类乳头多空病毒 (JC)：诱导仓鼠脑肿瘤
影响因子：
56.9
作者：
D. Walker;B. Padgett;G. ZuRhein;A. E. Albert;R. Marsh
通讯作者：
R. Marsh
持续性 DNA 病毒感染的疾病和机制：潜伏期和细胞转化。
DOI：
10.1093/infdis/132.2.209
发表时间：
1975
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Joseph S. Pagano
通讯作者：
Joseph S. Pagano
在转化细胞和易感细胞的异核体中生产 SV40 病毒。
DOI：
10.1073/pnas.58.4.1396
发表时间：
1967
影响因子：
11.1
作者：
J. Watkins;R. Dulbecco
通讯作者：
R. Dulbecco