The changing pattern of common respiratory viruses among children from 2018 to 2021 in Wuhan, China.
The changing pattern of common respiratory viruses among children from 2018 to 2021 in Wuhan, China.
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DOI：
10.1007/s00705-023-05891-7
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发表时间：
2023-11-14
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
--
作者：
儿童急性呼吸道感染是一项全球公共卫生挑战。由于冠状病毒病（COVID-19）大流行，广泛实施了患者隔离、保持社交距离、洗手和戴口罩等非药物干预措施，影响了常见呼吸道病毒的传播。本研究旨在了解武汉市14岁以下儿童感染COVID-19前后呼吸道病毒的流行病学特征。2018年1月至2021年12月在中国武汉两家医院采集年龄< 14岁患者的呼吸道标本。用免疫荧光法鉴定了7种呼吸道病毒。病原菌谱和季节特征分析。2020年2月以后，就诊次数和病毒检出率大幅下降。呼吸道病毒检出率在1月和12月达到高峰，在2月和8月急剧下降。2021年的检出率低于2018年和2019年。呼吸道合胞病毒（RSV）在COVID-19大流行前后的1岁以下和1 - 4岁儿童中被确定为主要病原体。在5-14岁儿童中，在COVID-19大流行之前检测到的流感病毒最高，在疫情之后检测到的呼吸道合胞病毒最高。RSV是合并感染中最常见的病毒。本研究揭示了2018 - 2021年常见呼吸道病毒的流行病学特征。涉及儿童呼吸道感染的病原体谱部分发生了变化。非药物干预措施减少了普通病毒传播的机会，但也造成了“免疫债务”，当武汉疫情得到控制时，这可能会产生负面影响。在线版本包含补充材料，下载地址：10.1007/s00705-023-05891-7。
Acute respiratory infections in children are a global public health challenge. Owing to the coronavirus disease (COVID-19) pandemic, non-pharmaceutical interventions, including patient isolation, social distancing, hand washing, and mask wearing, have been widely implemented, impacting the transmission of common respiratory viruses. The aim of this study was to clarify the epidemiological features of respiratory viruses in children less than 14 years of age in Wuhan before and after COVID-19. Respiratory specimens were collected from patients aged < 14 years at two hospitals in Wuhan, China, from January 2018 to December 2021. Seven respiratory viruses were identified using an immunofluorescence assay. Pathogen profiles and seasonality were analysed. The number of visits and virus detection rate decreased dramatically after February 2020. The respiratory virus detection rate peaked in January and December and decreased dramatically in February and August. The detection rate was lower in 2021 than in 2018 and 2019. Respiratory syncytial virus (RSV) was identified as the leading pathogen in children aged < 1 year and 1–4 years before and after the COVID-19 pandemic. In children aged 5–14 years, influenza virus was detected at the highest rate before, and RSV after, the COVID-19 pandemic. RSV was the most common virus in coinfections. This study revealed the epidemiological patterns of common respiratory viruses from 2018 to 2021. The spectrum of pathogens involved in paediatric respiratory infections had partly changed. Non-pharmaceutical interventions resulted in fewer opportunities for the spread of common viruses but also in an “immunity debt” that could have negative consequences when the pandemic is under control in Wuhan. The online version contains supplementary material available at 10.1007/s00705-023-05891-7.
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影响因子：
16.6
作者：
Huang QS;Wood T;Jelley L;Jennings T;Jefferies S;Daniells K;Nesdale A;Dowell T;Turner N;Campbell-Stokes P;Balm M;Dobinson HC;Grant CC;James S;Aminisani N;Ralston J;Gunn W;Bocacao J;Danielewicz J;Moncrieff T;McNeill A;Lopez L;Waite B;Kiedrzynski T;Schrader H;Gray R;Cook K;Currin D;Engelbrecht C;Tapurau W;Emmerton L;Martin M;Baker MG;Taylor S;Trenholme A;Wong C;Lawrence S;McArthur C;Stanley A;Roberts S;Rahnama F;Bennett J;Mansell C;Dilcher M;Werno A;Grant J;van der Linden A;Youngblood B;Thomas PG;NPIsImpactOnFlu Consortium;Webby RJ
通讯作者：
Webby RJ
DOI：
10.1016/s0140-6736(22)00478-0
发表时间：
2022-05-28
期刊：
Lancet (London, England)
影响因子：
--
作者：
Li Y;Wang X;Blau DM;Caballero MT;Feikin DR;Gill CJ;Madhi SA;Omer SB;Simões EAF;Campbell H;Pariente AB;Bardach D;Bassat Q;Casalegno JS;Chakhunashvili G;Crawford N;Danilenko D;Do LAH;Echavarria M;Gentile A;Gordon A;Heikkinen T;Huang QS;Jullien S;Krishnan A;Lopez EL;Markić J;Mira-Iglesias A;Moore HC;Moyes J;Mwananyanda L;Nokes DJ;Noordeen F;Obodai E;Palani N;Romero C;Salimi V;Satav A;Seo E;Shchomak Z;Singleton R;Stolyarov K;Stoszek SK;von Gottberg A;Wurzel D;Yoshida LM;Yung CF;Zar HJ;Respiratory Virus Global Epidemiology Network;Nair H;RESCEU investigators
通讯作者：
RESCEU investigators
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
12.7
作者：
Liu, Pengcheng;Xu, Menghua;Xu, Jin
通讯作者：
Xu, Jin
影响因子：
3.4
作者：
Kasle, David A.;Torabi, Sina J.;Manes, R. Peter
通讯作者：
Manes, R. Peter