Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.
Self-protection of individual CD4+ T cells against R5 HIV-1 infection by the synthesis of anti-viral CCR5 ligands.
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DOI：
10.1371/journal.pone.0003481
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Lewis GK
中科院分区：
文献类型：
--
作者：
Guan Y;Abdelwahab S;Kamin-Lewis R;DeVico AL;Lewis GK
已经确定，CD 8+和CD 4 + T细胞旁分泌抗病毒CCR 5配体可以阻断HIV-1的R5和双嗜性分离株对活化的CD 4 + T细胞的感染。相比之下，因为CD 4 + T细胞可以被HIV-1感染，并且至少一些亚群分泌抗病毒CCR 5配体，所以这些配体可能通过自分泌以及旁分泌途径来保护免受HIV-1感染。在这里，我们使用一个模型的主要CD 4 + T细胞反应在体外显示，个别的CD 4 + T细胞分泌抗病毒CCR 5配体是“自我保护”的感染与R5，但不是X4株的HIV-1。这种保护对于分泌抗病毒CCR 5配体的CD 4 + T细胞是选择性的，因为相同培养物中的活化的CD 4 + T细胞仍然可以被R5 HIV-1感染。这些数据与该系统中的自分泌保护途径最一致，并表明在HIV-1感染期间病毒变体和CD 4 + T细胞表型的出现存在以前未被认识到的选择性压力。
It is well established that paracrine secretion of anti-viral CCR5 ligands by CD8+ and CD4+ T cells can block the infection of activated CD4+ T cells by R5 and dual-tropic isolates of HIV-1. By contrast, because CD4+ T cells can be infected by HIV-1 and at least some subsets secrete anti-viral CCR5 ligands, it is possible that these ligands protect against HIV-1 via autocrine as well as paracrine pathways. Here we use a model primary CD4+ T cell response in vitro to show that individual CD4+ T cells that secrete anti-viral CCR5 ligands are ‘self-protected’ against infection with R5 but not X4 strains of HIV-1. This protection is selective for CD4+ T cells that secrete anti-viral CCR5 ligands in that activated CD4+ T cells in the same cultures remain infectable with R5 HIV-1. These data are most consistent with an autocrine pathway of protection in this system and indicate a previously unappreciated selective pressure on the emergence of viral variants and CD4+ T cell phenotypes during HIV-1 infection.
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影响因子：
56.9
作者：
COCCHI, F;DEVICO, AL;LUSSO, P
通讯作者：
LUSSO, P
DOI：
10.1073/pnas.95.15.8869
发表时间：
1998-07-21
影响因子：
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影响因子：
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