Linking Lipid Metabolism to Chromatin Regulation in Aging.
Linking Lipid Metabolism to Chromatin Regulation in Aging.
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DOI：
10.1016/j.tcb.2018.09.004
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发表时间：
2019-03
影响因子：
19
通讯作者：
Brunet A
中科院分区：
文献类型：
--
作者：
Papsdorf K;Brunet A
生物体的寿命受到环境因素（包括饮食）和内部因素（特别是生殖状况）的强烈影响。脂质代谢对于适应外部条件或生殖至关重要。有趣的是，特定的脂质谱与寿命有关，某些脂质的摄取增加延长了C。elegans并改善人类的疾病表型。脂质如何影响寿命，以及脂质代谢在衰老过程中如何调节，才刚刚开始解开。本文综述了脂质在长寿中的调节和作用的最新进展，重点是衰老和年龄相关疾病中脂质代谢和染色质状态之间的相互作用。
The lifespan of an organism is strongly influenced by environmental factors, including diet, and by internal factors, notably reproductive status. Lipid metabolism is critical for adaptation to external conditions or reproduction. Interestingly, specific lipid profiles are associated with longevity and increased uptake of certain lipids extends longevity in C. elegans and ameliorates disease phenotypes in humans. How lipids impact longevity, and how lipid metabolism is regulated during aging, is just beginning to be unraveled. This review describes recent advances in the regulation and role of lipids in longevity, focusing on the interaction between lipid metabolism and chromatin states in aging and age-related diseases.
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影响因子：
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作者：
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通讯作者：
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Khaitovich P
影响因子：
4.2
作者：
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通讯作者：
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影响因子：
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作者：
Cosentino, Claudia;Mostoslavsky, Raul
通讯作者：
Mostoslavsky, Raul