Optical cochlear implants: evaluation of surgical approach and laser parameters in cats.
Optical cochlear implants: evaluation of surgical approach and laser parameters in cats.
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DOI：
10.1016/j.heares.2010.06.021
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发表时间：
2010-10-01
期刊：
影响因子：
2.8
通讯作者：
Richter, Claus-Peter
中科院分区：
文献类型：
--
作者：
Rajguru, Suhrud M.;Matic, Agnella Izzo;Robinson, Alan M.;Fishman, Andrew J.;Moreno, Laura E.;Bradley, Allison;Vujanovic, Irena;Breen, Joe;Wells, Jonathon D.;Bendett, Mark;Richter, Claus-Peter
以往的研究表明，红外辐射的神经刺激具有空间选择性，并说明了红外刺激听觉神经元的潜力。本研究展示了微型脉冲红外刺激器在猫体内慢性植入的应用，量化了其刺激听觉神经元的有效性和短期安全性。通过在猫耳蜗基底侧钻孔的耳蜗造口插入光纤来实现神经元的红外刺激，并通过测量复合动作电位（CAPs）来表征。在不同的脉冲持续时间、辐射暴露和脉冲重复率下，用红外刺激神经元。短至50 μs的脉冲持续时间可以成功地唤起正常耳蜗和耳聋耳蜗的cap。连续刺激以200脉冲/秒，200毫瓦/脉冲，100 μs脉冲持续时间。在长达10小时的连续红外刺激下，观察到稳定的CAP振幅。结合组织学数据，结果表明脉冲红外刺激不会导致可检测到的急性组织损伤，并验证了刺激参数，可用于未来基于脉冲红外的慢性植入物。
Previous research has shown that neural stimulation with infrared radiation (IR) is spatially selective and illustrated the potential of IR in stimulating auditory neurons. The present work demonstrates the application of a miniaturized pulsed IR stimulator for chronic implantation in cats, quantifies its efficacy, and short-term safety in stimulating auditory neurons. IR stimulation of the neurons was achieved using an optical fiber inserted through a cochleostomy drilled in the basal turn of the cat cochlea and was characterized by measuring compound action potentials (CAPs). Neurons were stimulated with IR at various pulse durations, radiant exposures, and pulse repetition rates. Pulse durations as short as 50 μs were successful in evoking CAPs in normal as well as deafened cochleae. Continual stimulation was provided at 200 pulses per second, at 200 mW per pulse, and 100 μs pulse duration. Stable CAP amplitudes were observed for up to ten hours of continual IR stimulation. Combined with histological data, the results suggest that pulsed IR stimulation does not lead to detectable acute tissue damage and validate the stimulation parameters that can be used in future chronic implants based on pulsed IR.
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