Anterior optic nerve blood flow in experimental optic atrophy.

Anterior optic nerve blood flow in experimental optic atrophy.
复制标题

实验性视神经萎缩中的前视神经血流量。

DOI:
--
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发表时间:
1985
影响因子:
4.4
通讯作者:
J. Weiter
J. Weiter
中科院分区:
医学2区
文献类型:
--
作者:
J. Sebag;G. Feke;F. Delori;J. Weiter

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本研究试图确定神经源性视神经萎缩是否会导致视神经前部循环的改变,并确定无创性测量活体血流的技术与微球分布的比较。5只猫接受了眼眶尖部的单侧视神经切断和对侧眼的假手术。术后2~3个月,荧光素血管造影均未发现异常。激光多普勒测量显示,体内萎缩的视神经头的毛细血管中的红细胞速度下降了53%。视盘反射测量活体前视神经血容量显示萎缩的视神经头的毛细血管血容量减少了51%。根据这些非侵入性测量计算血流量,显示视神经萎缩平均减少74%。微球分布的组织学研究表明,视神经萎缩时流向前视神经的平均减少了80%。这些结果表明,在原发性神经源性视神经萎缩中,视神经前部血流量显著减少。这项研究还表明,微球分布的组织学评估证实了血流的非侵入性测量。
This study attempts to establish whether neurogenic optic atrophy induces changes in anterior optic nerve circulation and to determine how noninvasive techniques of measuring blood flow in vivo compare to microsphere distribution. Five cats underwent unilateral optic nerve transection in the orbital apex and a sham procedure in the contralateral eye. Two to three months later, no abnormalities were detected by fluorescein angiography. Laser Doppler measurements demonstrated a 53% decrease in red blood cell speed through the capillaries of the atrophic optic nerve heads in vivo. Optic disk reflectance measurements of anterior optic nerve blood volume in vivo demonstrated a 51% decrease in the estimated blood volume of the capillaries in atrophic optic nerve heads. Flow was calculated on the basis of these noninvasive measurements and demonstrated an average decrease of 74% in optic atrophy. Histologic studies of microsphere distribution demonstrated an average decrease of 80% in flow to the anterior optic nerve in optic atrophy. These results suggest that anterior optic nerve blood flow is significantly reduced in primary neurogenic optic atrophy. This study also demonstrates that the noninvasive measurements of blood flow are substantiated by histologic evaluation of microsphere distribution.
DOI: 10.1001/archopht.1981.03930010635009
发表时间: 1981-01-01
影响因子: --
作者:
QUIGLEY, HA;ADDICKS, EM;MAUMENEE, AE
通讯作者: MAUMENEE, AE
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DOI: 10.1001/archopht.1983.01040010971026
发表时间: 1983
期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子: --
作者:
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DOI: --
发表时间: 1982
影响因子: 4.4
作者:
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实验性视盘苍白中视神经乳头毛细血管的定量研究。
DOI: 10.1016/0002-9394(82)90461-5
发表时间: 1982
影响因子: 4.2
作者:
Quigley,HA;Hohman,RM;Addicks,EM
通讯作者: Addicks,EM