Anterior optic nerve blood flow in experimental optic atrophy.
Anterior optic nerve blood flow in experimental optic atrophy.
复制标题
实验性视神经萎缩中的前视神经血流量。
DOI:
--
复制
发表时间:
1985
影响因子:
4.4
通讯作者:
J. Weiter
中科院分区:
文献类型:
--
作者:
J. Sebag;G. Feke;F. Delori;J. Weiter
This study attempts to establish whether neurogenic optic atrophy induces changes in anterior optic nerve circulation and to determine how noninvasive techniques of measuring blood flow in vivo compare to microsphere distribution. Five cats underwent unilateral optic nerve transection in the orbital apex and a sham procedure in the contralateral eye. Two to three months later, no abnormalities were detected by fluorescein angiography. Laser Doppler measurements demonstrated a 53% decrease in red blood cell speed through the capillaries of the atrophic optic nerve heads in vivo. Optic disk reflectance measurements of anterior optic nerve blood volume in vivo demonstrated a 51% decrease in the estimated blood volume of the capillaries in atrophic optic nerve heads. Flow was calculated on the basis of these noninvasive measurements and demonstrated an average decrease of 74% in optic atrophy. Histologic studies of microsphere distribution demonstrated an average decrease of 80% in flow to the anterior optic nerve in optic atrophy. These results suggest that anterior optic nerve blood flow is significantly reduced in primary neurogenic optic atrophy. This study also demonstrates that the noninvasive measurements of blood flow are substantiated by histologic evaluation of microsphere distribution.
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影响因子:
--
作者:
QUIGLEY, HA;ADDICKS, EM;MAUMENEE, AE
通讯作者:
MAUMENEE, AE
DOI:
10.1001/archopht.1983.01040010971026
发表时间:
1983
期刊:
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子:
--
作者:
Green,GJ;Feke,GT;Goger,DG;McMeel,JW
通讯作者:
McMeel,JW
影响因子:
4.4
作者:
Riva,CE;Grunwald,JE;Sinclair,SH
通讯作者:
Sinclair,SH
影响因子:
4.2
作者:
Quigley,HA;Hohman,RM;Addicks,EM
通讯作者:
Addicks,EM