Variations in the temporal pattern of perforant pathway stimulation control the activity in the mesolimbic pathway
Variations in the temporal pattern of perforant pathway stimulation control the activity in the mesolimbic pathway
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穿通通路刺激的时间模式的变化控制中脑边缘通路的活动
DOI：
10.1016/j.neuroimage.2012.09.001
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发表时间：
2013
期刊：
影响因子：
5.7
通讯作者：
F. Angenstein
中科院分区：
文献类型：
--
作者：
Helbing;G. Werner;F. Angenstein
通过功能性磁共振成像（fMRI）和电生理记录，在美托咪定麻醉大鼠中研究了穿孔通路高频刺激（即100 Hz）期间海马结构中的信号处理以及由此产生的信号向皮质和皮质下结构的传播。用20个脉冲的脉冲串（每秒一个脉冲串）或连续施加的脉冲刺激穿支通路。刺激持续时间调整为8 s（短）或30 s（长）。一般来说，延长刺激持续时间只会引起fMRI反应的局部扩散，但不会改变fMRI反应的幅度。这与电生理反应一致，也保持不变。相比之下，增加一个刺激序列中的脉冲数（即从突发刺激变为连续刺激）会导致局部fMRI反应的扩散和增加，并伴随着神经元反应模式的改变。连续刺激也触发了额外的功能磁共振成像反应，在隔核，前扣带皮层/内侧前额叶皮层，腹侧被盖区/黑质。海马结构外的fMRI反应的出现需要至少3个连续的刺激序列，其特征在于区域特异性血流动力学反应功能。因此，一旦触发，连续刺激引起的fMRI反应的顺序出现在海马结构开始，随后在腹侧被盖区/黑质和前扣带皮层/内侧前额叶皮层的信号变化，并最终在脑桥核。这些结果表明，高频刺激海马结构可以激活中脑边缘通路，提供了重复刺激。
Signal processing in the hippocampal formation and resultant signal propagation to cortical and subcortical structures during high frequency stimulation (i.e. 100Hz) of the perforant pathway was studied in medetomidine anesthetized rats by functional magnetic resonance imaging (fMRI) and electrophysiological recordings. The perforant pathway was stimulated with bursts of 20 pulses, one burst per second, or with continuously applied pulses. The stimulation duration was adjusted to 8s (short) or 30s (long). In general, extending the stimulation duration only caused a local spreading of the fMRI response, but no changes in the magnitude of the fMRI response. This was in agreement with the electrophysiological responses, which also remained unchanged. In contrast, increasing the number of pulses in one stimulus train (i.e. changing from burst to continuous stimulation), caused both spreading and an increase in local fMRI responses that were accompanied by an altered neuronal response pattern. Continuous stimulation also triggered additional fMRI responses in the septum, nucleus accumbens, anterior cingulate cortex/medial prefrontal cortex, and ventral tegmental area/substantia nigra. The appearance of fMRI responses outside the hippocampal formation required at least 3 consecutive stimulation trains, characterized by region specific hemodynamic response functions. Thus, once triggered, continuous stimulation caused a sequential appearance in fMRI responses starting in the hippocampal formation, followed by signal changes in the ventral tegmental area/substantia nigra and anterior cingulate cortex/medial prefrontal cortex and eventually in the nucleus accumbens. These results indicate that high frequency stimulation of the hippocampal formation can activate the mesolimbic pathway, provided that repetitive stimulations are applied.
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影响因子：
5.7
作者：
Angenstein, Frank;Kammerer, Elena;Frey, Sabine
通讯作者：
Frey, Sabine
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DOI：
--
发表时间：
1977
期刊：
The Journal of comparative neurology
影响因子：
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作者：
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通讯作者：
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作者：
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影响因子：
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作者：
Kocharyan, Ara;Fernandes, Priscilla;Hamel, Edith
通讯作者：
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影响因子：
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作者：
Logothetis, NK;Pauls, J;Oeltermann, A
通讯作者：
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