Blood-Based Therapies to Combat Aging.
Blood-Based Therapies to Combat Aging.
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DOI：
10.1159/000492573
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发表时间：
2019
期刊：
影响因子：
3.5
通讯作者：
Castellano JM
中科院分区：
文献类型：
--
作者：
Castellano JM
与衰老过程相关的功能障碍将衰老定位为发展毁灭性疾病和增加医疗费用的罪魁祸首。许多与年龄相关的疾病，其中年龄增加的风险是神经系统疾病，没有有效的治疗，包括阿尔茨海默氏病。随着未来几十年中老年人的比例继续上升，与老龄化有关的费用预计将大幅增加。已经出现了各种方法来满足治疗衰老及其相关病症的临床需求，包括旨在延长寿命，减缓衰老过程本身和改善健康寿命的方法。一种新兴的方法利用血液中循环的分子来限制或逆转全身各个器官的衰老。目前正在努力将这些发现转化为新的治疗方法，利用血液中与青春相关的分子的活性。在这里，我们讨论了在这个竞技场中基于血液的方法的现状。尽管血液制品可以想象地被应用为治疗范例的明显容易性，但我们提出仍然存在挑战，这可以通过确定靶向治疗的共同途径的机制研究来克服。
Dysfunction associated with the aging process positions aging as a leading culprit for development of devastating diseases and mounting healthcare costs. Many age-associated conditions for which aging increases risk are neurological disorders with no effective treatments, including Alzheimer’s disease. As the proportion of aged individuals continues to rise in the coming decades, aging-related costs are expected to increase dramatically. Diverse approaches have emerged to meet the clinical need to treat aging and its associated conditions, including those aimed at increasing longevity, slowing the aging process itself, and improving healthspan. An emerging approach takes advantage of molecules circulating in the blood to limit or reverse aspects of aging in various organs throughout the body. Efforts are underway to translate these findings into novel therapeutics that harness the activity of youth-associated molecules present within blood. Here we discuss the current state of blood-based approaches in this arena. Despite the apparent ease with which blood products might conceivably be applied as treatment paradigms, we propose that challenges nonetheless exist, which may be overcome with mechanistic studies that identify common pathways for targeted therapeutics.
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影响因子：
4.6
作者：
Castellano JM;Palner M;Li SB;Freeman GM Jr;Nguyen A;Shen B;Stan T;Mosher KI;Chin FT;de Lecea L;Luo J;Wyss-Coray T
通讯作者：
Wyss-Coray T
影响因子：
--
作者：
Baker, Laura D.;Barsness, Suzanne M.;Borson, Soo;Merriam, George R.;Friedman, Seth D.;Craft, Suzanne;Vitiello, Michael V.
通讯作者：
Vitiello, Michael V.
影响因子：
29
作者：
Egerman MA;Cadena SM;Gilbert JA;Meyer A;Nelson HN;Swalley SE;Mallozzi C;Jacobi C;Jennings LL;Clay I;Laurent G;Ma S;Brachat S;Lach-Trifilieff E;Shavlakadze T;Trendelenburg AU;Brack AS;Glass DJ
通讯作者：
Glass DJ
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
5
作者：
Dennis CV;Suh LS;Rodriguez ML;Kril JJ;Sutherland GT
通讯作者：
Sutherland GT