The four types of Tregs in malignant lymphomas.
The four types of Tregs in malignant lymphomas.
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DOI：
10.1186/1756-8722-4-50
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发表时间：
2011-12-09
影响因子：
28.5
通讯作者：
Ke XY
中科院分区：
文献类型：
--
作者：
Wang J;Ke XY
调节性T细胞（Regulatory T cells，Tcells）是CD 4 + T细胞的特化亚群，其作用是抑制其他免疫细胞的活化。胸腺素代表淋巴瘤和宿主微环境之间相互作用的重要调节剂。淋巴瘤是一组严重的和经常致命的淋巴细胞恶性疾病。最近的研究表明，一些淋巴瘤T细胞可能采用Treg特征。患者中Treg表型和基因型的评估可提供许多类型的淋巴瘤的结果预测，包括弥漫性大B细胞淋巴瘤、滤泡性淋巴瘤、皮肤T细胞淋巴瘤和霍奇金淋巴瘤。基于Tcl 3在淋巴瘤中的特征性作用，我们可以将各种作用分为四组：（a）抑制性Tcl 3;（B）恶性Tcl 3;（c）直接肿瘤杀伤性Tcl 3;和（d）不胜任的Tcl 3。分为四组在预测预后和设计用于治疗淋巴瘤的基于Tregs的免疫疗法中是重要的。在具有淋巴瘤的患者中，其中Tcl 3作为抑制性Tcl 3或恶性Tcl 3，抗肿瘤细胞毒性被抑制，因此Tcl 3的数量减少与良好的预后相关。相比之下，在具有淋巴瘤的患者中，其中T细胞作为肿瘤杀伤T细胞和无功能T细胞，抗肿瘤细胞毒性增强或抗自身免疫T细胞活性减弱，因此T细胞数量增加与良好预后相关，T细胞数量减少与不良预后相关。然而，TdR在淋巴瘤患者中的各种作用的潜在机制仍然未知。因此，在这方面需要进一步的研究，以及在不同的淋巴瘤的预后因素和治疗策略的实用性。
Regulatory T cells (Tregs) are a specialized subpopulation of CD4+ T cells, which act to suppress the activation of other immune cells. Tregs represent important modulators for the interaction between lymphomas and host microenvironment. Lymphomas are a group of serious and frequently fatal malignant diseases of lymphocytes. Recent studies revealed that some lymphoma T cells might adopt a Treg profile. Assessment of Treg phenotypes and genotypes in patients may offer prediction of outcome in many types of lymphomas including diffuse large B-cell lymphoma, follicular lymphoma, cutaneous T cell lymphoma, and Hodgkin's lymphoma. Based on characterized roles of Tregs in lymphomas, we can categorize the various roles into four groups: (a) suppressor Tregs; (b) malignant Tregs; (c) direct tumor-killing Tregs; and (d) incompetent Tregs. The classification into four groups is significant in predicting prognosis and designing Tregs-based immunotherapies for treating lymphomas. In patients with lymphomas where Tregs serve either as suppressor Tregs or malignant Tregs, anti-tumor cytotoxicity is suppressed thus decreased numbers of Tregs are associated with a good prognosis. In contrast, in patients with lymphomas where Tregs serve as tumor-killing Tregs and incompetent Tregs, anti-tumor cytotoxicity is enhanced or anti-autoimmune Tregs activities are weakened thus increased numbers of Tregs are associated with a good prognosis and reduced numbers of Tregs are associated with a poor prognosis. However, the mechanisms underlying the various roles of Tregs in patients with lymphomas remain unknown. Therefore, further research is needed in this regard as well as the utility of Tregs as prognostic factors and therapy strategies in different lymphomas.
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影响因子：
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作者：
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通讯作者：
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DOI：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
通讯作者：
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影响因子：
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作者：
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