Integrating microRNAs into a system biology approach to acute lung injury.
Integrating microRNAs into a system biology approach to acute lung injury.
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DOI：
10.1016/j.trsl.2011.01.010
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Zhou T;Garcia JG;Zhang W
急性肺损伤（ALI），包括呼吸机引起的肺损伤（VILI）和更严重的急性呼吸窘迫综合征（ARDS），是常见且复杂的炎症性肺病，可能受到各种遗传和非遗传因素的影响。使用候选基因方法，与免疫反应和炎症途径相关的遗传变异已被识别并与 ALI 相关。由于基因表达是介于 DNA 序列变异和更高水平的细胞或全身表型之间的中间表型，因此基因表达调控网络的图示可能会增强对疾病易感性和炎症性肺部综合征发展的理解。 MicroRNA (miRNA) 已成为一类新型基因调节因子，在 ALI 等复杂疾病中发挥着关键作用。对 ALI 和 VILI 动物模型中的整体 miRNA 谱进行比较，发现了先前与免疫反应和炎症途径有关的几种 miRNA（例如 miR-146a、miR-155）。因此，通过调节这些生物过程和途径中的靶基因，miRNA 可能有助于 ALI 的发展。虽然这一研究还处于起步阶段，但 miRNA 有潜力成为炎症性肺病综合模型的关键组成部分，该模型是通过系统生物学方法构建的，该方法整合了遗传、基因组、蛋白质组、表观遗传以及环境刺激信息。鉴于其在免疫和炎症反应调节中的特别公认的作用，miRNA还可以作为ALI/ARDS或VILI的新治疗靶点和生物标志物，从而促进急性炎症性肺病患者个体化医疗的实现。
Acute lung injury (ALI), including the ventilator-induced lung injury (VILI) and the more severe acute respiratory distress syndrome (ARDS), are common and complex inflammatory lung diseases potentially affected by various genetic and non-genetic factors. Using the candidate gene approach, genetic variants associated with immune response and inflammatory pathways have been identified and implicated in ALI. Since gene expression is an intermediate phenotype that resides between DNA sequence variation and higher level cellular or whole-body phenotypes, the illustration of gene expression regulatory networks could potentially enhance understanding of disease susceptibility and the development of inflammatory lung syndromes. MicroRNAs (miRNAs) have emerged as a novel class of gene regulators which play critical roles in complex diseases including ALI. Comparisons of global miRNA profiles in animal models of ALI and VILI identified several miRNAs (e.g., miR-146a, miR-155) previously implicated in immune response and inflammatory pathways. Therefore, via regulation of target genes in these biological processes and pathways, miRNAs potentially contribute to the development of ALI. While this line of inquiry exists at a nascent stage, miRNAs have the potential to be critical components of a comprehensive model for inflammatory lung disease built by a systems biology approach that integrates genetic, genomic, proteomic, epigenetic as well environmental stimuli information. Given their particularly recognized role in regulation of immune and inflammatory responses, miRNAs also serve as novel therapeutic targets and biomarkers for ALI/ARDS or VILI, thus facilitating the realization of personalized medicine for individuals with acute inflammatory lung disease.
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影响因子：
9.9
作者：
通讯作者：
--
DOI：
10.1038/nrrheum.2010.81
发表时间：
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期刊：
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影响因子：
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作者：
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