Mouse models of cancers: opportunities to address heterogeneity of human cancer and evaluate therapeutic strategies.
Mouse models of cancers: opportunities to address heterogeneity of human cancer and evaluate therapeutic strategies.
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DOI：
10.1007/s00109-010-0644-z
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发表时间：
2010-11
影响因子：
4.7
通讯作者：
Nevins, Joseph R.
中科院分区：
文献类型：
--
作者：
Andrechek, Eran R.;Nevins, Joseph R.
人类乳腺癌的异质性已经在形态学、分子和基因组水平上得到了很好的描述。这种异质性是有效治疗乳腺癌的最大障碍之一，因为反映不同疾病机制的不同形式的乳腺癌需要不同的治疗方法。虽然癌症的小鼠模型传统上被用来简化人类疾病的研究，但我们认为也有机会模拟人类癌症的复杂性和异质性。在这里，我们说明了小鼠模型在病理和基因表达的异质性方面与人类的相似之处。然后，我们提供了基因表达分析方法与当前治疗方案结合使用以模拟个性化治疗方案时的潜力的说明。
The heterogeneity of human breast cancer has been well described at the morphological, molecular, and genomic levels. This heterogeneity presents one of the greatest obstacles in the effective treatment of breast cancer since the distinct forms of breast cancer that reflect distinct mechanisms of disease will require distinct therapies. Although mouse models of cancer have traditionally been used to simplify the study of human disease, we suggest that there are opportunities to also model the complexity and heterogeneity of human cancer. Here, we illustrate the similarities of mouse models to the human condition in the heterogeneity of both pathologies and gene expression. We then provide an illustration of the potential of gene expression analysis methods when used in conjunction with current treatment options to model individualized therapeutic regimes.
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影响因子：
12.3
作者：
Herschkowitz JI;Simin K;Weigman VJ;Mikaelian I;Usary J;Hu Z;Rasmussen KE;Jones LP;Assefnia S;Chandrasekharan S;Backlund MG;Yin Y;Khramtsov AI;Bastein R;Quackenbush J;Glazer RI;Brown PH;Green JE;Kopelovich L;Furth PA;Palazzo JP;Olopade OI;Bernard PS;Churchill GA;Van Dyke T;Perou CM
通讯作者：
Perou CM
影响因子：
64.8
作者：
Mullighan, Charles G.;Goorha, Salil;Downing, James R.
通讯作者：
Downing, James R.
影响因子：
2.5
作者：
Medina, Daniel
通讯作者：
Medina, Daniel
影响因子：
64.5
作者：
STEWART, TA;PATTENGALE, PK;LEDER, P
通讯作者：
LEDER, P
DOI：
10.1073/pnas.0932692100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Sorlie, T;Tibshirani, R;Botstein, D
通讯作者：
Botstein, D