Hydrogen sulfide and polysulfides as biological mediators.
Hydrogen sulfide and polysulfides as biological mediators.
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DOI：
10.3390/molecules191016146
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发表时间：
2014-10-09
期刊：
影响因子：
--
通讯作者：
Kimura H
中科院分区：
文献类型：
--
作者：
Kimura H
硫化氢（H2S）被认为是具有多种作用的生物介质，例如神经调节、血管张力调节、细胞保护、抗炎、氧传感、血管生成和线粒体能量产生。由胱硫醚β-合酶（CBS）、胱硫醚γ-裂解酶（CSE）和3-巯基丙酮酸硫转移酶（3MST）产生。CBS的活性被S-腺苷甲硫氨酸（SAM）和谷胱甘肽化增强，而被一氧化氮（NO）和一氧化碳（CO）抑制。CSE和半胱氨酸氨基转移酶（CAT）的活性（产生3MST底物3-巯基丙酮酸（3MP））受Ca 2+调节。H2S在线粒体中通过硫化物醌氧化还原酶（SQR）、硫双加氧酶和罗丹酸盐的顺序作用被氧化为硫代硫酸盐。H2S的产生和清除速率决定其细胞浓度。已发现多硫化物（H2Sn）存在于脑中并激活瞬时受体电位锚蛋白1（TRPA 1）通道，促进核因子红细胞2相关因子2（Nrf2）易位至核，并通过硫化（巯基化）靶半胱氨酸残基来抑制磷酸酶和张力蛋白同源物（PTEN）的活性。H2S和NO之间的串扰也在心脏保护以及血管张力的调节中起重要作用。H2S、多硫化物及其与NO的交互作用可介导多种生理和病理生理反应。
Hydrogen sulfide (H2S) is recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy. It is produced by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST). The activity of CBS is enhanced by S-adenosyl methionine (SAM) and glutathionylation, while it is inhibited by nitric oxide (NO) and carbon monoxide (CO). The activity of CSE and cysteine aminotransferase (CAT), which produces the 3MST substrate 3-mercaptopyruvate (3MP), is regulated by Ca2+. H2S is oxidized to thiosulfate in mitochondria through the sequential action of sulfide quinone oxidoreductase (SQR), sulfur dioxygenase, and rhodanese. The rates of the production and clearance of H2S determine its cellular concentration. Polysulfides (H2Sn) have been found to occur in the brain and activate transient receptor potential ankyrin 1 (TRPA1) channels, facilitate the translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) to the nucleus, and suppress the activity of phosphatase and tensin homolog (PTEN) by sulfurating (sulfhydrating) the target cysteine residues. A cross talk between H2S and NO also plays an important role in cardioprotection as well as regulation of the vascular tone. H2S, polysulfides, and their cross talk with NO may mediate various physiological and pathophysiological responses.
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影响因子：
20.1
作者：
Calvert JW;Jha S;Gundewar S;Elrod JW;Ramachandran A;Pattillo CB;Kevil CG;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
15
作者：
Filipovic, Milos R.;Miljkovic, Jan Lj;Nauser, Thomas;Royzen, Maksim;Klos, Katharina;Shubina, Tatyana;Koppenol, Willem H.;Lippard, Stephen J.;Ivanovic-Burmazovic, Ivana
通讯作者：
Ivanovic-Burmazovic, Ivana
影响因子：
20.1
作者：
Mustafa AK;Sikka G;Gazi SK;Steppan J;Jung SM;Bhunia AK;Barodka VM;Gazi FK;Barrow RK;Wang R;Amzel LM;Berkowitz DE;Snyder SH
通讯作者：
Snyder SH
DOI：
10.1016/0006-291x(83)90472-2
发表时间：
1983-01-01
影响因子：
3.1
作者：
CONNER, J;RUSSELL, PJ
通讯作者：
RUSSELL, PJ
影响因子：
3.9
作者：
Francoleon, Nestor E.;Carrington, Samantha J.;Fukuto, Jon M.
通讯作者：
Fukuto, Jon M.