Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation.
Effect of ventilation on cerebral oxygenation during exercise: insights from canonical correlation.
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运动期间通气对脑氧合的影响：典型相关性的见解。
DOI：
10.1016/j.resp.2009.02.013
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发表时间：
2009-04-30
影响因子：
2.3
通讯作者：
Roach, Robert C.
中科院分区：
文献类型：
--
作者：
Heine, Martin;Subudhi, Andrew W.;Roach, Robert C.
我们测试的假设，大脑脱氧近最大运动强度是由过度通气介导的，通过低碳酸血症引起的脑血流量减少，利用典型相关分析（CCA），以确定心肺变化对脑氧合的相对影响，近红外光谱（NIRS）评估。23名受试者在常氧和低氧条件下进行递增运动试验。通气量（V ~ E）变化与呼吸代偿点（RCP）后潮气末CO2（PET CO2）和NIRS密切相关（r2 >0.97）。然而，与我们的预期相反，CBF速度（CBFv）与NIRS测量值的方差最小（r2 < 0.56），CBFv的减少并不伴随着脑血容量的减少。这些结果表明，虽然大脑脱氧与过度通气，这是不是唯一的解释低碳酸血症引起的CBFv的减少。CCA显示，静脉对NIRS贡献的相对增加解释了比CBFv减少更大的脑氧合变化。
We tested hypothesis that cerebral deoxygenation near maximal exercise intensity is mediated by hyperventilation, via hypocapnia-induced reductions in cerebral blood flow, by utilizing canonical correlation analysis (CCA) to determine the relative influence of cardiopulmonary changes on cerebral oxygenation, as assessed by near infrared spectroscopy (NIRS). Twenty-three subjects performed incremental exercise tests under normoxic and hypoxic conditions. Changes in ventilation (V̇E) were strongly correlated with end-tidal CO2 (PET CO2) and NIRS after the respiratory compensation point (RCP) (r2 >0.97). However, in contrast to our expectations, CBF velocity (CBFv) shared the least amount of variance with NIRS measurements (r2 < 0.56) and the reduction in CBFv was not accompanied by a reduction in cerebral blood volume. These results demonstrate that while cerebral deoxygenation was associated with hyperventilation, it was not solely explained by hypocapnia-induced reductions in CBFv. CCA revealed that a relative increase in the venous contribution to NIRS explained a larger amount of variation in cerebral oxygenation than reductions CBFv.
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影响因子：
2.3
作者：
Bhambhani, Yagesh;Malik, Rohit;Mookerjee, Swapan
通讯作者：
Mookerjee, Swapan
影响因子：
2.4
作者：
Stolz, Erwin;Fox, Bettina C.;Kaps, Manfred
通讯作者：
Kaps, Manfred
DOI：
10.1152/ajpheart.01104.2007
发表时间：
2008-01-01
影响因子：
4.8
作者：
Subudhi, Andrew W.;Lorenz, Matthew C.;Roach, Robert C.
通讯作者：
Roach, Robert C.
DOI：
10.1152/ajpregu.00442.2007
发表时间：
2007-11-01
影响因子：
2.8
作者：
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通讯作者：
Dempsey, Jerome A.
影响因子：
3.4
作者：
Sherry, A;Henson, RK
通讯作者：
Henson, RK