The role of gastric secretagogues in regulating gastric histamine release in vivo.
The role of gastric secretagogues in regulating gastric histamine release in vivo.
复制标题
胃促分泌剂在体内调节胃组胺释放中的作用。
DOI：
10.1016/0016-5085(92)90083-b
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发表时间：
1992
期刊：
影响因子：
29.4
通讯作者：
Payne,NA
中科院分区：
文献类型：
--
作者：
Gerber,JG;Payne,NA
研究了短期动脉灌注五胃泌素和甲胆碱对杂种狗体内组胺和n τ-甲基组胺分泌率的影响。选择刺激胃酸分泌的五胃泌素和甲胆碱剂量相等。通过测定促分泌剂输注过程中各时间点动脉和胃静脉血浆组胺和n τ-甲基组胺浓度，评估组胺和n τ-甲基组胺分泌率，并连续监测胃血流量。采用稳定同位素稀释技术，采用气相色谱/负离子化学电离质谱法分析血浆组胺和n τ-甲基组胺浓度。组胺和n τ-甲基组胺分泌率的计算方法是用静脉血浆浓度减去动脉血浆浓度，再乘以胃血浆流量。注射pentagastrin导致组胺释放从0时的1.5±0.7 ng/min大幅增加到5分钟时的72±20 ng/min， 20分钟时下降到20±8 ng/min的平台。nτ -甲基组胺分泌率从基线时的6.7±1.9 ng/min增加到10分钟时的最大值42.5±13.1 ng/min，并在五胃泌素输注期间保持增加。甲胆碱输注与组胺释放小幅但持续增加相关，从基线的1.6±0.6 ng/min增加到5分钟时的5.9±1.7 ng/min。甲胆碱对n τ-甲基组胺分泌率无影响。胃血流量的变化与组胺释放的程度大致平行，但甲胆碱本身是胃血管扩张剂。我们的数据表明，与甲胆碱相比，pentagastrin是一种更有效的胃组胺释放刺激物，组胺在胃泌素刺激的胃酸输出中的整体作用可能与组胺在胆碱能介导的胃酸输出中的作用不同。
The effect of short-term intragastric arterial infusion of pentagastrin and methacholine on histamine and Nτ-Methyl histamine secretory rates was evaluated in mongrel dogs in vivo. Doses of pentagastrin and methacholine were chosen that stimulate gastric acid secretion equivalently. Histamine and Nτ-Methyl histamine secretory rates were evaluated by measuring the arterial and gastric venous plasma histamine and Nτ-Methyl histamine concentrations at several time points during the secretagogue infusion, and gastric blood flow was continuously monitored. Histamine and Nτ-Methyl histamine plasma concentrations were analyzed by stable isotope dilution technique using gas chromatography/ negative ion-chemical ionization mass spectrometry. Histamine and Nτ-Methyl histamine secretory rates were calculated by subtracting the arterial from the venous plasma concentrations and multiplying the difference by gastric plasma flow. Infusion of pentagastrin resulted in large pulsed increase of histamine release from 1.5 ± 0.7 ng/min at time 0 to 72 ± 20 ng/min at 5 minutes, which decreased to a plateau of 20 ± 8 ng/min at 20 minutes. Nτ-Methyl histamine secretory rate increased from 6.7 ± 1.9 ng/min at baseline to a maximum of 42.5 ± 13.1 ng/min at 10 minutes, and the increase was maintained for the duration of the pentagastrin infusion. Methacholine infusion was associated with a small but sustained increase in histamine release, from a baseline of 1.6 ± 0.6 ng/ min to 5.9 ± 1.7 ng/min at 5 minutes. Nτ-Methyl histamine secretory rate was unchanged by methacholine. Gastric blood flow changes to pentagastrin roughly paralleled the extent of histamine release, but methacholine is a gastric vasodilator in its own right. Our data indicate that pentagastrin is a much more effective stimulator of gastric histamine release than methacholine and that the overall role of histamine in gastrin-stimulated acid output is likely to be different from the role of histamine in cholinergic-mediated gastric acid output.
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甲乙酰胺（一种作用于 H2 受体的组胺拮抗剂）可抑制狗的胃酸分泌。
影响因子：
29.4
作者：
M. Grossman;S. Konturek
通讯作者：
S. Konturek
大鼠胃粘膜中含有并形成组胺的细胞的定位。
影响因子：
3.7
作者：
R. Thunberg
通讯作者：
R. Thunberg
五肽胃泌素对狗胃粘膜组胺的影响。
DOI：
10.1152/ajpgi.1985.248.3.g369
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Redfern,JS;Thirlby,R;Feldman,M;Richardson,CT
通讯作者：
Richardson,CT
胃刺激剂对分离的犬壁细胞[14 C]氨基比林积累的增强相互作用。
影响因子：
29.4
作者：
Soll,AH
通讯作者：
Soll,AH
DOI：
--
发表时间：
1987
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Gerber,JG;Barnes,JS
通讯作者：
Barnes,JS