Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation.
复制标题
DOI：
10.1371/journal.pone.0258285
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Dosdall DJ
中科院分区：
文献类型：
--
作者：
Lange M;Hirahara AM;Ranjan R;Stoddard GJ;Dosdall DJ
心房中的慢传导区和传导阻滞被认为是导致心律失常的条件。在持续性房颤(房颤)的背景下研究慢传导区域的大小和分布可能有助于为房颤患者制定更好的治疗策略。在本工作中，我们研究了对照组和持续性房颤山羊慢传导区的大小和数量的差异，以及传播方向对这些病理性传导区发展的影响。从左心房顶端的心外膜心房电活动与生理性起搏周期长度和最短的捕获周期长度进行光学映射。记录被转换为局部激活时间和传导速度测量。识别出传导速度慢(小于)的区域。统计连通区域的大小和非连通区域的个数，从不同的垂直方向传播。我们发现，在我们的15个持续性房颤山羊记录中，对过早刺激的反应，慢传导区域显著增加(24.4±4.3%增加到36.6±4.4%，p<；0.001)。这一增长是由于已有区域的尺寸从(3.7±0.89[mm~2]增加到6.36±0.91[mm~2]，p=0.014)，而不是由于新的慢传导区的产生(11.6±1.8vs.13±1.9，p=0.242)。在12个对照山羊的记录中，没有发现从基线起搏到提前起搏的增加。同样，在对照动物中，慢传导区的大小和计数没有显著变化。
Slow conduction areas and conduction block in the atria are considered pro-arrhythmic conditions. Studies examining the size and distribution of slow conduction regions in the context of persistent atrial fibrillation (AF) may help to develop improved therapeutic strategies for patients with AF. In this work, we studied the differences of size and number in slow conduction areas between control and persistent AF goats and the influence of propagation direction on the development of these pathological conduction areas. Epicardial atrial electrical activations from the left atrial roof were optically mapped with physiological pacing cycle lengths and for the shortest captured cycle lengths. The recordings were converted to local activation times and conduction velocity measures. Regions with slow conduction velocity (less than ) were identified. The size of the connected regions and the number of non-connected regions were counted for propagation from different orthogonal directions. We found that regions of slow conduction significantly increases in our 15 persistent AF goat recordings in response to premature stimulation (24.4±4.3% increase to 36.6±4.4%, p < 0.001). This increase is driven by an increase of size from (3.70±0.89[mm2] to 6.36±0.91[mm2], p = 0.014) for already existing regions and not by generation of new slow conduction regions (11.6±1.8 vs. 13±1.9, p = 0.242). In 12 control goat recordings, no increase from baseline pacing to premature pacing was found. Similarly, size of the slow conduction areas and the count did not change significantly in control animals.
登录
查看更多内容
影响因子：
20.1
作者：
SPACH, MS;MILLER, WT;JOHNSON, EA
通讯作者：
JOHNSON, EA
影响因子：
2.7
作者：
Starreveld, Roeliene;de Groot, Natasja M. S.
通讯作者：
de Groot, Natasja M. S.
影响因子：
2
作者：
Calkins, Hugh;Hindricks, Gerhard;Yamane, Teiichi
通讯作者：
Yamane, Teiichi
影响因子：
8.4
作者：
Krul, Sebastien P. J.;Berger, Wouter R.;de Groot, Joris R.
通讯作者：
de Groot, Joris R.
DOI：
10.1152/ajpheart.00484.2008
发表时间：
2008-09
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Pope AJ;Sands GB;Smaill BH;LeGrice IJ
通讯作者：
LeGrice IJ