Pupillary Response to Cognitive Demand in Parkinson's Disease: A Pilot Study.
Pupillary Response to Cognitive Demand in Parkinson's Disease: A Pilot Study.
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DOI：
10.3389/fnagi.2018.00090
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发表时间：
2018
影响因子：
4.8
通讯作者：
Devos H
中科院分区：
文献类型：
--
作者：
Kahya M;Moon S;Lyons KE;Pahwa R;Akinwuntan AE;Devos H
以前的研究表明，瞳孔反应，认知工作量的生理指标，反映了健康的年轻人和老年人的认知需求。然而，认知负荷和认知需求之间的关系在帕金森病（PD）仍然不清楚。本初步研究的目的是检查16名PD非痴呆患者（年龄，中位数（Q1-Q3）：68（62-72）; 10名男性）和10名对照参与者（年龄：63（59-67）; 2名男性）在字母-数字排序（LNS）任务中对认知需求的瞳孔反应，年龄，教育和蒙特利尔认知评估（莫卡）评分匹配。采用混合模型分析研究认知负荷的变化，作为两组认知需求增加的结果。正如预期的那样，两组之间在LNS上的认知评分没有差异。认知工作量，例如更大的瞳孔扩张，增加了两组的认知需求（p = 0.003）。未发现显著的组间（p = 0.23）或相互作用效应（p = 0.45）。此外，在较高字母-数字（LN）负荷下完成任务的个体与在较低LN负荷下完成任务的个体相比，对增加的认知需求的反应不同（p < 0.001），无论疾病状态如何。总体而言，研究结果表明，瞳孔反应反映了非痴呆PD患者和健康对照者的认知需求增加。需要进一步的研究，以调查瞳孔反应的认知需求增加PD痴呆患者相比，非痴呆PD和健康对照。瞳孔反应反映了患有PD的非痴呆患者和健康对照两者的认知需求。尽管由于功率不足而不显著，但是在整个测试过程中，患有PD的非痴呆个体与健康对照相比具有增加的认知工作负荷。瞳孔反应可能是患有PD的非痴呆个体的认知需求的有效测量。瞳孔反应可用于检测PD患者的认知功能障碍
Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson’s disease (PD) remains unclear. The aim of this pilot study was to examine the pupillary response to cognitive demand in a letter-number sequencing (LNS) task between 16 non-demented individuals with PD (age, median (Q1–Q3): 68 (62–72); 10 males) and 10 control participants (age: 63 (59–67); 2 males), matched for age, education, and Montreal Cognitive Assessment (MOCA) scores. A mixed model analysis was employed to investigate cognitive workload changes as a result of incremental cognitive demand for both groups. As expected, no differences were found in cognitive scores on the LNS between groups. Cognitive workload, exemplified by greater pupil dilation, increased with incremental cognitive demand in both groups (p = 0.003). No significant between-group (p = 0.23) or interaction effects were found (p = 0.45). In addition, individuals who achieved to complete the task at higher letter-number (LN) load responded differently to increased cognitive demand compared with those who completed at lower LN load (p < 0.001), regardless of disease status. Overall, the findings indicated that pupillary response reflects incremental cognitive demand in non-demented people with PD and healthy controls. Further research is needed to investigate the pupillary response to incremental cognitive demand of PD patients with dementia compared to non-demented PD and healthy controls. Pupillary response reflects cognitive demand in both non-demented people with PD and healthy controls Although not significant due to insufficient power, non-demented individuals with PD had increased cognitive workload compared to the healthy controls throughout the testing Pupillary response may be a valid measure of cognitive demand in non-demented individuals with PD In future, pupillary response might be used to detect cognitive impairment in individuals with PD Highlights
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DOI：
10.1016/j.cortex.2017.09.025
发表时间：
2017-12
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Elman JA;Panizzon MS;Hagler DJ Jr;Eyler LT;Granholm EL;Fennema-Notestine C;Lyons MJ;McEvoy LK;Franz CE;Dale AM;Kremen WS
通讯作者：
Kremen WS
影响因子：
--
作者：
Mhyre, Timothy R;Boyd, James T;Hamill, Robert W;Maguire-Zeiss, Kathleen A
通讯作者：
Maguire-Zeiss, Kathleen A
影响因子：
2.4
作者：
Attar N;Schneps MH;Pomplun M
通讯作者：
Pomplun M
DOI：
10.1080/13825580903265681
发表时间：
2010-05
期刊：
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
影响因子：
--
作者：
Allard ES;Wadlinger HA;Isaacowitz DM
通讯作者：
Isaacowitz DM
影响因子：
4.7
作者：
Eckstein MK;Guerra-Carrillo B;Miller Singley AT;Bunge SA
通讯作者：
Bunge SA