Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
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DOI：
10.1038/tp.2015.167
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发表时间：
2015-11-10
影响因子：
6.8
通讯作者：
Glerup S
中科院分区：
文献类型：
--
作者：
Buttenschøn HN;Demontis D;Kaas M;Elfving B;Mølgaard S;Gustafsen C;Kaerlev L;Petersen CM;Børglum AD;Mors O;Glerup S
神经营养因子与抑郁症的关系已被研究。本研究的目的是将这一焦点扩大到分拣蛋白（sortilin），一种参与神经营养信号传导的受体。对152名抑郁症患者和216名对照者的血清分拣蛋白水平进行了研究，成功分析了SORT 1基因内的8个遗传标记与抑郁症的相关性。使用Sequenom MassARRAY平台进行基因分型。所有的人都返回了一份问卷，并参加了半结构化的诊断访谈。分拣蛋白水平通过免疫测定法测量，血清分拣蛋白水平的潜在决定因素通过广义线性模型评估。先前的研究中测量了血清脑源性神经营养因子（BDNF）和血管内皮生长因子（VEGF）的水平。我们确定了一个显着增加血清分拣蛋白水平与对照组相比（P=0.0002），血清分拣蛋白水平和相应的BDNF和VEGF水平之间的显着正相关。没有一个基因型SNP与抑郁症相关。其他分析表明，血清分拣蛋白水平受其他几个因素的影响。在我们最终的多变量模型中，酒精摄入量和体重指数，以及抑郁症，血清BDNF和血清VEGF被确定为血清分拣蛋白水平的预测因子。总之，结果表明循环分拣蛋白在抑郁症中的作用可能与神经营养因子的活性改变有关。
Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus to sortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depression and 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for association with depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaire and participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potential determinants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) were measured in previous studies. We identified a significant increase of serum sortilin levels in depressed individuals compared with controls (P=0.0002) and significant positive correlation between serum sortilin levels and the corresponding levels of BDNF and VEGF. None of the genotyped SNPs were associated with depression. Additional analyses showed that the serum sortilin level was influenced by several other factors. Alcohol intake and body mass index, as well as depression, serum BDNF and serum VEGF were identified as predictors of serum sortilin levels in our final multivariate model. In conclusion, the results suggest a role of circulating sortilin in depression which may relate to altered activity of neurotrophic factors.
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影响因子：
3.7
作者：
Harris LW;Pietsch S;Cheng TM;Schwarz E;Guest PC;Bahn S
通讯作者：
Bahn S
影响因子：
6.5
作者：
Bi, Lipeng;Chiang, John Y. L.;Li, Tiangang
通讯作者：
Li, Tiangang
影响因子：
11
作者：
Baum, A. E.;Akula, N.;McMahon, F. J.
通讯作者：
McMahon, F. J.
影响因子：
3.7
作者：
Bus, B. A. A.;Molendijk, M. L.;Voshaar, R. C. Oude
通讯作者：
Voshaar, R. C. Oude
影响因子：
30.8
作者：
Lambert, Jean-Charles;Ibrahim-Verbaas, Carla A.;Harold, Denise;Naj, Adam C.;Sims, Rebecca;Bellenguez, Celine;Jun, Gyungah;DeStefano, Anita L.;Bis, Joshua C.;Beecham, Gary W.;Grenier-Boley, Benjamin;Russo, Giancarlo;Thornton-Wells, Tricia A.;Jones, Nicola;Smith, Albert V.;Chouraki, Vincent;Thomas, Charlene;Ikram, M. Arfan;Zelenika, Diana;Vardarajan, Badri N.;Kamatani, Yoichiro;Lin, Chiao-Feng;Gerrish, Amy;Schmidt, Helena;Kunkle, Brian;Dunstan, Melanie L.;Ruiz, Agustin;Bihoreau, Marie-Therese;Choi, Seung-Hoan;Reitz, Christiane;Pasquier, Florence;Hollingworth, Paul;Ramirez, Alfredo;Hanon, Olivier;Fitzpatrick, Annette L.;Buxbaum, Joseph D.;Campion, Dominique;Crane, Paul K.;Baldwin, Clinton;Becker, Tim;Gudnason, Vilmundur;Cruchaga, Carlos;Craig, David;Amin, Najaf;Berr, Claudine;Lopez, Oscar L.;De Jager, Philip L.;Deramecourt, Vincent;Johnston, Janet A.;Evans, Denis;Lovestone, Simon;Letenneur, Luc;Moron, Francisco J.;Rubinsztein, David C.;Eiriksdottir, Gudny;Sleegers, Kristel;Goate, Alison M.;Fievet, Nathalie;Huentelman, Matthew J.;Gill, Michael;Brown, Kristelle;Kamboh, M. Ilyas;Keller, Lina;Barberger-Gateau, Pascale;McGuinness, Bernadette;Larson, Eric B.;Green, Robert;Myers, Amanda J.;Dufouil, Carole;Todd, Stephen;Wallon, David;Love, Seth;Rogaeva, Ekaterina;Gallacher, John;St George-Hyslop, Peter;Clarimon, Jordi;Lleo, Alberto;Bayer, Anthony;Tsuang, Debby W.;Yu, Lei;Tsolaki, Magda;Bossu, Paola;Spalletta, Gianfranco;Proitsi, Petroula;Collinge, John;Sorbi, Sandro;Sanchez-Garcia, Florentino;Fox, Nick C.;Hardy, John;Naranjo, Maria Candida Deniz;Bosco, Paolo;Clarke, Robert;Brayne, Carol;Galimberti, Daniela;Mancuso, Michelangelo;Matthews, Fiona;Moebus, Susanne;Mecocci, Patrizia;Del Zompo, Maria;Maier, Wolfgang;Hampel, Harald;Pilotto, Alberto;Bullido, Maria;Panza, Francesco;Caffarra, Paolo;Nacmias, Benedetta;Gilbert, John R.;Mayhaus, Manuel;Lannfelt, Lars;Hakonarson, Hakon;Pichler, Sabrina;Carrasquillo, Minerva M.;Ingelsson, Martin;Beekly, Duane;Alvarez, Victoria;Zou, Fanggeng;Valladares, Otto;Younkin, Steven G.;Coto, Eliecer;Hamilton-Nelson, Kara L.;Gu, Wei;Razquin, Cristina;Pastor, Pau;Mateo, Ignacio;Owen, Michael J.;Faber, Kelley M.;Jonsson, Palmi V.;Combarros, Onofre;O'Donovan, Michael C.;Cantwell, Laura B.;Soininen, Hilkka;Blacker, Deborah;Mead, Simon;Mosley, Thomas H., Jr.;Bennett, David A.;Harris, Tamara B.;Fratiglioni, Laura;Holmes, Clive;de Bruijn, Renee F. A. G.;Passmore, Peter;Montine, Thomas J.;Bettens, Karolien;Rotter, Jerome I.;Brice, Alexis;Morgan, Kevin;Foroud, Tatiana M.;Kukull, Walter A.;Hannequin, Didier;Powell, John F.;Nalls, Michael A.;Ritchie, Karen;Lunetta, Kathryn L.;Kauwe, John S. K.;Boerwinkle, Eric;Riemenschneider, Matthias;Boada, Merce;Hiltunen, Mikko;Martin, Eden R.;Schmidt, Reinhold;Rujescu, Dan;Wang, Li-San;Dartigues, Jean-Francois;Mayeux, Richard;Tzourio, Christophe;Hofman, Albert;Noethen, Markus M.;Graff, Caroline;Psaty, Bruce M.;Jones, Lesley;Haines, Jonathan L.;Holmans, Peter A.;Lathrop, Mark;Pericak-Vance, Margaret A.;Launer, Lenore J.;Farrer, Lindsay A.;van Duijn, Cornelia M.;Van Broeckhoven, Christine;Moskvina, Valentina;Seshadri, Sudha;Williams, Julie;Schellenberg, Gerard D.;Amouyel, Philippe
通讯作者：
Amouyel, Philippe