Leukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members
Leukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members
复制标题
巴西人及其家庭成员全身侵袭性牙周炎中放线菌聚集菌的白细胞毒性
DOI：
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发表时间：
2013
影响因子：
2.7
通讯作者：
R. Rêgo
中科院分区：
文献类型：
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作者：
V. Silveira;Marcia Bessa Nogueira;N. A. Nogueira;V. Lima;F. Furlaneto;R. Rêgo
目的研究广泛性侵袭性牙周炎（GAgP）患者及其家庭成员（FM）中放线菌聚集菌克隆的白毒素启动子类型。材料与方法对35例GAgP患者（33.9±7.1年）、33例FM患者（22.8±11.4年）和41例慢性牙周炎患者（44.1±9.4年）进行菌斑指数、牙龈指数、探诊深度（PD）和临床附着水平（CAL）的临床分析。在每位患者的四个近端牙周部位（>PD和>CAL）采集龈下生物膜样本。聚合酶链反应（PCR）证实了放线菌属及其白毒性克隆的存在。结果GAgP患者23例（51.1%）、CP患者16例（30.1%）出现放线菌菌群。轻度白毒性菌株37例（94.8%），高度白毒性菌株2例（5.1%）。FM组有侵袭性牙周炎（AgP） 10例（30.3%），CP 12例（36.3%），牙周健康或牙龈炎11例（33.3%），放线菌球菌阳性12.2%。细菌阳性的GAgP患者的全口PD和CAL高于阴性的GAgP患者（p< 0.05），放线菌comitans的存在与GAgP呈正相关（优势比为3.1，可信区间为1.4 ~ 7.0,p=0.009）。结论放线菌孢子虫的存在与GAgP的临床状况有关，大多数患者表现为广泛性疾病和轻度白毒性克隆。GAgP患者亲属多表现为CP或AgP。
Objective The purpose of this study was to examine the leukotoxin promoter types of Aggregatibacter actinomycetemcomitans clones in subjects with generalized aggressive periodontitis (GAgP) and in their family members (FM). Material and Methods Thirty-five patients with GAgP (33.9±7.1 years), 33 of their FM (22.8±11.4 years), and 41 patients with chronic periodontitis (CP) (44.1±9.4 years) were clinically analyzed using the plaque index, gingival index, probing depth (PD), and clinical attachment level (CAL). Subgingival biofilm samples were collected from four interproximal periodontal sites (>PD and >CAL) of each patient. The presence of A. actinomycetemcomitans and its leukotoxic clone was confirmed by polymerase chain reaction (PCR). Results A. actinomycetemcomitans was observed in 23 (51.1%) GAgP patients and 16 (30.1%) CP patients. Thirty-seven (94.8%) patients showed minimally leukotoxic strains and 2 (5.1%) showed highly leukotoxic strains. In the FM group, 10 (30.3%) had aggressive periodontitis (AgP), 12 (36.3%) had CP, 11 (33.3%) were periodontally healthy or had gingivitis, and 12.2% were A. actinomycetemcomitans positive. Greater full mouth PD and CAL were observed in GAgP patients positive for the bacteria than those negative for it (p<;0.05), and the presence of A. actinomycetemcomitans positively correlated with GAgP (Odds ratio, 3.1; confidence interval, 1.4-7.0; p=0.009). Conclusions The presence of A. actinomycetemcomitans was associated with the clinical condition of GAgP, with most patients exhibiting a generalized form of the disease and minimally leukotoxic clones. Most of the relatives of GAgP patients presented either CP or AgP.
影响因子：
4.3
作者：
Colombo AP;Boches SK;Cotton SL;Goodson JM;Kent R;Haffajee AD;Socransky SS;Hasturk H;Van Dyke TE;Dewhirst F;Paster BJ
通讯作者：
Paster BJ
伴放线放线杆菌血清型、白细胞毒素基因类型和溶原性与牙周病状态的关系。
DOI：
10.1111/j.1600-0722.1997.tb00246.x
发表时间：
1997
期刊：
European journal of oral sciences.
影响因子：
--
作者：
BarrettoTinoco,EM;Stevens,R;Haubek,D;Lai,CH;Balachandran,S;Preus,H
通讯作者：
Preus,H