Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery
Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery
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具有肽-Au缀合物的自组装热敏发光纳米颗粒用于细胞成像和药物输送
DOI：
10.1016/j.cclet.2019.06.032
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发表时间：
2020-03
影响因子：
9.1
通讯作者：
Su Zhiqiang
中科院分区：
文献类型：
--
作者：
Zhang Xiaoyuan;Liu Wei;Wang Haixia;Zhao Xinne;Zhang Zhenfang;Nienhaus Gerd Ulrich;Shang Li;Su Zhiqiang
一种简便高效的策略被开发出来，以构建一种多功能的抗癌药物传递平台，具有主动靶向、受控药物释放和荧光成像的特点，用于实时控制传递。为此，热敏性聚(N-异丙基丙烯酰胺)(PNIPAM)纳米球被修饰多肽-Au簇合物作为智能纳米药物平台。设计了一种复杂的三功能多肽，用于释放抗癌药物阿霉素(DOX)，靶向细胞，并还原Au~(3+)离子形成发光的Au团簇。重要的是，多肽-金团簇部分通过酰胺键而不是非共价相互作用连接到PNIPAM纳米球上，显著提高了其在生物介质中的稳定性和药物释放效率。体外实验表明，在生理条件下，DOX以高效、可控的方式释放。
A facile and efficient strategy has been developed to fabricate a multifunctional, theranostic anticancer drug delivery platform featuring active targeting, controlled drug release and fluorescence imaging for real-time control of delivery. To this end, thermosensitive poly(N-isopropyl acrylamide)(PNIPAM) nanospheres are decorated with peptide-Au cluster conjugates as a smart nanomedicine platform. A sophisticated trifunctional peptide is designed to release the anticancer drug doxorubicin(DOX), target cells and reduce Au~(3+) ions to form luminescent Au clusters. Importantly, the peptide-Au cluster moieties are attached to the PNIPAM nanospheres via amide bonds rather than noncovalent interactions, significantly improving their stability in biological medium and drug release efficiency. The in vitro experiments showed that DOX was released in an efficient and controlled manner under physiological conditions.
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