T cell Ig and mucin domain proteins and immunity.

T cell Ig and mucin domain proteins and immunity.
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DOI:
10.4049/jimmunol.0902937
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发表时间:
2010-03-15
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
通讯作者:
Kane LP
Kane LP
中科院分区:
其他
文献类型:
--
作者:
Kane LP

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跨膜免疫球蛋白和粘蛋白结构域 (TIM) 家族的蛋白质由啮齿动物和人类免疫系统内的多种细胞类型表达。过去几年的研究表明,这些蛋白质可能是免疫反应治疗操纵的有希望的靶标。这篇综述讨论了在了解 TIM 蛋白在免疫系统中的功能方面所取得的进展,以及在最终靶向 TIM 蛋白以增强或抑制免疫的道路上仍然存在的一些未解决的问题。
Proteins of the transmembrane immunoglobulin and mucin domain (TIM) family are expressed by multiple cell types within the immune systems of rodents and humans. Studies over the last several years have suggested that these proteins may be promising targets for therapeutic manipulation of immune responses. This review discusses the progress that has been made in understanding TIM protein function in the immune system, as well as some of the unresolved issues that remain on the road to eventually targeting TIM proteins for enhancing or inhibiting immunity.
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发表时间: 1996-08-15
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