Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols.
Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols.
复制标题
病理生理学，糖尿病心肌病的临床特征：天然多酚的治疗潜力。
DOI：
10.3389/fnut.2020.564352
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发表时间：
2020
影响因子：
5
通讯作者：
Jin JO
中科院分区：
文献类型：
--
作者：
Atale N;Yadav D;Rani V;Jin JO
糖尿病心肌病（DCM）是通过氧化应激、局部炎症和纤维化引起的代谢活动紊乱的结果，也是全球范围内死亡的主要原因。糖尿病患者的心血管疾病已成为诊断和制定治疗原型的挑战。有必要更好地了解细胞病理生理学，以揭示治疗靶点，并防止由于高血糖引起的心血管疾病的进展。糖尿病患者心脏细胞外基质中胶原和整合素水平发生了重要变化，这是糖尿病患者心脏重塑的原因。本综述探讨了对植物化学物质如何在糖尿病下提供心脏保护的机制的理解，沿着注意事项，并提供了这些药物作为开发治疗扩张型心肌病药物原型的未来前景。因此，在这里我们总结了各种植物提取物和天然多酚在糖尿病心肌病临床前和细胞培养模型中的作用。此外，还说明了所选多酚的潜在用途，其改善了对糖尿病性心肌病的治疗功效。
Diabetic cardiomyopathy (DCM) is an outcome of disturbances in metabolic activities through oxidative stress, local inflammation, and fibrosis, as well as a prime cause of fatality worldwide. Cardiovascular disorders in diabetic individuals have become a challenge in diagnosis and formulation of treatment prototype. It is necessary to have a better understanding of cellular pathophysiology that reveal the therapeutic targets and prevent the progression of cardiovascular diseases due to hyperglycemia. Critical changes in levels of collagen and integrin have been observed in the extracellular matrix of heart, which was responsible for cardiac remodeling in diabetic patients. This review explored the understanding of the mechanisms of how the phytochemicals provide cardioprotection under diabetes along with the caveats and provide future perspectives on these agents as prototypes for the development of drugs for managing DCM. Thus, here we summarized the effect of various plant extracts and natural polyphenols tested in preclinical and cell culture models of diabetic cardiomyopathy. Further, the potential use of selected polyphenols that improved the therapeutic efficacy against diabetic cardiomyopathy is also illustrated.
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影响因子：
19
作者：
Abedin, Monika;King, Nicole
通讯作者：
King, Nicole
影响因子：
4
作者：
Aju, B. Y.;Rajalakshmi, R.;Mini, S.
通讯作者：
Mini, S.
影响因子：
5.8
作者：
Atale, Neha;Gupta, Khushboo;Rani, Vibha
通讯作者：
Rani, Vibha
影响因子：
7.6
作者：
Cesario, J;Higgins, ET;Plaks, JE
通讯作者：
Plaks, JE
DOI：
10.1186/s10020-018-0060-3
发表时间：
2018-11-23
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Fishman SL;Sonmez H;Basman C;Singh V;Poretsky L
通讯作者：
Poretsky L