Diverse evolutionary paths to cell adhesion.

Diverse evolutionary paths to cell adhesion.
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DOI:
10.1016/j.tcb.2010.08.002
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发表时间:
2010-12
影响因子:
19
通讯作者:
King, Nicole
King, Nicole
中科院分区:
生物学1区
文献类型:
--
作者:
Abedin, Monika;King, Nicole

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动物、真菌、植物和其他多细胞生物的形态和生理多样性源于这样一个事实,即每个谱系在进化过程中独立获得多细胞性。每个谱系中多细胞起源的先决条件是稳定的细胞-细胞粘附或附着机制的进化。基因组学和细胞遗传学的最新进展允许进行比较研究,为细胞粘附的进化基础提供重要的见解。重建动物及其单细胞亲属中细胞连接蛋白的进化,证实了在向多细胞进化过渡过程中协同选择和创新的作用。对团藻的比较研究揭示了团藻多细胞性进化过程中伴随的特定分子变化。最后,动物和网骨藻之间的比较表明,在何种程度上的共同点和差异,在生物学上的单细胞祖先的影响,在每个血统的粘附机制的演变。了解细胞粘附的单细胞起源有助于阐明现代生物体中多细胞发育的基本细胞生物学。
The morphological and physiological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently during the course of evolution. A prerequisite for the origin of multicellularity in each lineage was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in genomics and phylogenetics allow comparative studies that provide critical insights into the evolutionary foundations of cell adhesion. Reconstructing the evolution of cell junction proteins in animals and their unicellular relatives exemplifies the roles of co-option and innovation during evolutionary transitions to multicellularity. Comparative studies of volvocine algae reveal specific molecular changes that accompanied the evolution of multicellularity in Volvox. Finally, comparisons between animals and Dictyostelium indicate the extent to which commonalities and differences in the biology of their unicellular ancestors influenced the evolution of adhesive mechanisms in each lineage. Understanding the unicellular ancestry of cell adhesion helps illuminate the basic cell biology of multicellular development in modern organisms.
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