Diverse evolutionary paths to cell adhesion.
Diverse evolutionary paths to cell adhesion.
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DOI:
10.1016/j.tcb.2010.08.002
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发表时间:
2010-12
影响因子:
19
通讯作者:
King, Nicole
中科院分区:
文献类型:
--
作者:
Abedin, Monika;King, Nicole
The morphological and physiological diversity of animals, fungi, plants, and other multicellular organisms stems from the fact that each lineage acquired multicellularity independently during the course of evolution. A prerequisite for the origin of multicellularity in each lineage was the evolution of mechanisms for stable cell-cell adhesion or attachment. Recent advances in genomics and phylogenetics allow comparative studies that provide critical insights into the evolutionary foundations of cell adhesion. Reconstructing the evolution of cell junction proteins in animals and their unicellular relatives exemplifies the roles of co-option and innovation during evolutionary transitions to multicellularity. Comparative studies of volvocine algae reveal specific molecular changes that accompanied the evolution of multicellularity in Volvox. Finally, comparisons between animals and Dictyostelium indicate the extent to which commonalities and differences in the biology of their unicellular ancestors influenced the evolution of adhesive mechanisms in each lineage. Understanding the unicellular ancestry of cell adhesion helps illuminate the basic cell biology of multicellular development in modern organisms.
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