Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs.
Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs.
复制标题
间充质干细胞来源的细胞外囊泡通过 microRNA 的转移影响疾病结果
DOI：
10.1186/s13287-018-1069-9
复制
发表时间：
2018-11-21
影响因子：
7.5
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Qiu G;Zheng G;Ge M;Wang J;Huang R;Shu Q;Xu J
间充质干细胞（MSC）是具有分化为多种类型细胞的能力的成体基质细胞。MSC代表了再生医学中一个有吸引力的选择，因为它们具有组织修复，免疫抑制和抗炎的多方面能力。最近的研究表明，MSC通过旁分泌活性发挥其作用，这至少部分地由细胞外囊泡（EV）介导。MSC衍生的EV（MSC-EV）可以通过将其组分如DNA、蛋白质/肽、mRNA、microRNA（miRNA）、脂质和细胞器转移到受体细胞来模拟亲本MSC的功能。本文就miRNA介导MSC-EVs在人类疾病模型中的作用及其机制进行综述。综述的前三个部分讨论了将miRNA分选到EV中，靶细胞对EV的摄取以及miRNA通过EV的功能转移。然后，我们描述了MSC-EV中miRNA的组成。接下来，我们提供了现有的证据，即MSC-EV通过转移其miRNA内容物影响肾脏，肝脏，心脏和大脑疾病的结果。总之，EV介导的miRNA转移在MSC的疾病调节能力中起重要作用。
Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into multiple types of cells. MSCs represent an attractive option in regenerative medicine due to their multifaceted abilities for tissue repair, immunosuppression, and anti-inflammation. Recent studies demonstrate that MSCs exert their effects via paracrine activity, which is at least partially mediated by extracellular vesicles (EVs). MSC-derived EVs (MSC-EVs) could mimic the function of parental MSCs by transferring their components such as DNA, proteins/peptides, mRNA, microRNA (miRNA), lipids, and organelles to recipient cells. In this review, we aim to summarize the mechanism and role of miRNA transfer in mediating the effects of MSC-EVs in the models of human diseases. The first three sections of the review discuss the sorting of miRNAs into EVs, uptake of EVs by target cells, and functional transfer of miRNAs via EVs. Then, we describe the composition of miRNAs in MSC-EVs. Next, we provide the existing evidence that MSC-EVs affect the outcomes of renal, liver, heart, and brain diseases by transferring their miRNA contents. In conclusion, EV-mediated miRNA transfer plays an important role in disease-modulating capacity of MSCs.
登录
查看更多内容
影响因子：
16
作者：
Lötvall J;Hill AF;Hochberg F;Buzás EI;Di Vizio D;Gardiner C;Gho YS;Kurochkin IV;Mathivanan S;Quesenberry P;Sahoo S;Tahara H;Wauben MH;Witwer KW;Théry C
通讯作者：
Théry C
影响因子：
3.7
作者：
Feng Y;Huang W;Wani M;Yu X;Ashraf M
通讯作者：
Ashraf M
影响因子：
24
作者：
Hare, Joshua M.;Traverse, Jay H.;Henry, Timothy D.;Dib, Nabil;Strumpf, Robert K.;Schulman, Steven P.;Gerstenblith, Gary;DeMaria, Anthony N.;Denktas, Ali E.;Gammon, Roger S.;Hermiller, James B., Jr.;Reisman, Mark A.;Schaer, Gary L.;Sherman, Warren
通讯作者：
Sherman, Warren
影响因子：
7.3
作者：
French KC;Antonyak MA;Cerione RA
通讯作者：
Cerione RA
影响因子：
13.6
作者：
Collino, Federica;Bruno, Stefania;Camussi, Giovanni
通讯作者：
Camussi, Giovanni