Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors.
Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors.
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DOI：
10.1016/j.jmr.2016.07.006
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发表时间：
2016-09
影响因子：
2.2
通讯作者：
Epel, Boris
中科院分区：
文献类型：
--
作者：
Christodoulou, Anthony G.;Redler, Gage;Clifford, Bryan;Liang, Zhi-Pei;Halpern, Howard J.;Epel, Boris
Hypoxic tumors are resistant to radiotherapy, motivating the development of tools to image local oxygen concentrations. It is generally believed that stable or chronic hypoxia is the source of resistance, but more recent work suggests a role for transient hypoxia. Conventional EPR imaging (EPRI) is capable of imaging tissue pO2 in vivo, with high pO2 resolution and 1 mm spatial resolution but low imaging speed (10 min temporal resolution for T1-based pO2 mapping), which makes it difficult to investigate the oxygen changes, e.g. transient hypoxia. Here we describe a new imaging method which accelerates dynamic EPR oxygen imaging, allowing 3D imaging at 2 frames per minute, fast enough to image transient hypoxia at the “speed limit” of observed pO2 change. The method centers on a low-rank tensor model that decouples the tradeoff between imaging speed, spatial coverage/resolution, and number of inversion times (pO2 accuracy). We present a specialized sparse sampling strategy and image reconstruction algorithm for use with this model. The quality and utility of the method is demonstrated in simulations and in vivo experiments in tumor bearing mice.
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DOI：
10.1002/cmr.b.20108
发表时间：
2008-04-01
影响因子：
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作者：
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