Expression of Lewis blood group antigens in cancerous and non-cancerous liver.
Expression of Lewis blood group antigens in cancerous and non-cancerous liver.
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Lewis 血型抗原在癌性和非癌性肝脏中的表达。
DOI：
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Y. Shimosato
中科院分区：
文献类型：
--
作者：
T. Kanai;S. Hirohashi;M. Upton;Y. Ino;Y. Shimosato
采用单克隆抗体免疫组化方法，研究了40例非癌性肝脏、20例肝细胞癌（HCC）、5例胆管癌（CC）和6例肝细胞胆管合并癌（Comb）中Lewis血型抗原Lewisa、Lewisb、Lewisx和Lewisy的表达。虽然正常肝细胞不表达这四种Lewis抗原中的任何一种，但在肝硬化假小叶周围的一些肝细胞中检测到Lewis抗原的表达。虽然在正常肝脏中无法检测到胆管上皮细胞中的Lewisx，但在一些非癌性肝病患者中可以检测到。在30%的HCC和100%的CC和Comb中检测到Lewisx和Lewisy。几乎所有病例的非癌性胆管上皮细胞都被抗lewisa和/或抗lewisb抗体强烈染色。Lewisa染色和Lewisb染色可以清楚地检测到Glisson鞘和假小叶内增生的胆管。Lewisa和Lewisb在非癌性肝细胞中从未检测到，仅在HCC中很少检测到，但在大多数CC和Comb病例中均有表达。这些结果表明，Lewisa和Lewisb是肝脏向胆道上皮细胞分化的有用标记物，并且Lewisx和Lewisy的表达可能与细胞增殖增加或改变的状态有关。
The expression of Lewis blood group antigens, Lewisa, Lewisb, Lewisx and Lewisy, in 40 non-cancerous livers and in 20 hepatocellular carcinomas (HCC), 5 cholangiocarcinomas (CC), and 6 combined hepatocellular and cholangiocarcinomas (Comb) was studied by immunohistochemistry using monoclonal antibodies. Although normal hepatocytes did not express any of the four Lewis antigens, Lewisy expression was detected in some hepatocytes at the periphery of pseudolobules in cirrhotic liver. While Lewisx in bile duct epithelial cells was undetectable in normal livers, it was detected in some cases with non-cancerous liver diseases. Lewisx and Lewisy were detected in 30% of HCC and 100% of CC and Comb. Non-cancerous bile duct epithelial cells in almost all instances were stained strongly by anti-Lewisa and/or anti-Lewisb antibody. Proliferating bile ductules within Glisson's sheath and pseudolobules could be clearly detected by Lewisa and Lewisb staining. Lewisa and Lewisb were never detected in non-cancerous hepatocytes, and were only rarely detected in HCC, but were expressed in most cases of CC and Comb. These results suggested that Lewisa and Lewisb are useful markers for differentiation towards biliary epithelial cells in the liver, and that Lewisx and Lewisy expression might be associated with states of increased or altered cell proliferation.
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DOI：
10.1016/s0021-9258(19)45389-1
发表时间：
1982-12
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
通讯作者：
John L. MagnaniS;Bo Nilssong;Manfred BrockhausSV;David Zopfl;Zenon SteplewskiJI;Hilary Koprowskill;V. Ginsburg
影响因子：
11.2
作者：
K. Fukushima;M. Hirota;P. Terasaki;A. Wakisaka;H. Togashi;D. Chia;N. Suyama;Y. Fukushi;E. Nudelman;S. Hakomori
通讯作者：
K. Fukushima;M. Hirota;P. Terasaki;A. Wakisaka;H. Togashi;D. Chia;N. Suyama;Y. Fukushi;E. Nudelman;S. Hakomori
Lewisa、Lewisb、X 和 Y 血型抗原在人结肠肿瘤和正常组织以及人肿瘤衍生细胞系中的表达。
影响因子：
11.2
作者：
Sakamoto,J;Furukawa,K;Cordon-Cardo,C;Yin,BW;Rettig,WJ;Oettgen,HF;Old,LJ;Lloyd,KO
通讯作者：
Lloyd,KO
Lewis 抗原在固定组织中的单克隆抗体定位。
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Ernst,C;Atkinson,B;Wysocka,M;Blaszczyk,M;Herlyn,M;Sears,H;Steplewski,Z;Koprowski,H
通讯作者：
Koprowski,H
DOI：
10.1073/pnas.82.20.7039
发表时间：
1985-01-01
影响因子：
11.1
作者：
HIROHASHI, S;CLAUSEN, H;HAKOMORI, S
通讯作者：
HAKOMORI, S