DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis.
DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis.
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David知识库：以基因为中心的数据库整合了异质基因注释资源，以促进高通量基因功能分析。
DOI：
10.1186/1471-2105-8-426
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发表时间：
2007-11-02
影响因子：
3
通讯作者：
Lempicki RA
中科院分区：
文献类型：
--
作者：
Sherman BT;Huang da W;Tan Q;Guo Y;Bour S;Liu D;Stephens R;Baseler MW;Lane HC;Lempicki RA
由于生物学研究的复杂性和分布性，我们目前的生物学知识分布在许多独立团体维护的许多冗余注释数据库中。分析人员通常需要访问这些生物信息学数据库中的许多数据库，以便为其基因整合全面的注释信息，这成为瓶颈之一，特别是对于与大型基因列表相关的分析任务。因此，高通量基因功能分析需要一个高度集中和随时可用的基因注释知识库。大卫知识库是围绕大卫基因概念建立的，这是一种将来自各种公共基因组资源的数千万个基因/蛋白质标识符聚集到大卫基因簇中的单连接方法。这种标识符的分组提高了交叉引用能力，特别是在NCBI和UniProt系统中，使40多个公开可用的功能注释源能够被大卫基因簇全面整合和集中。构成大卫知识库的简单、成对、文本格式文件可免费下载，用于各种数据分析用途。此外，组织良好的Web界面允许用户以高吞吐量的方式查询不同类型的异构注释。大卫知识库旨在促进高通量基因功能分析。对于一个给定的基因列表，它不仅提供了在一个集中的位置，广泛的异质性注释数据的快速访问，但也丰富了一个单独的基因的生物信息的水平。此外，整个大卫知识库可以免费下载或搜索。
Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually need to visit many of these bioinformatics databases in order to integrate comprehensive annotation information for their genes, which becomes one of the bottlenecks, particularly for the analytic task associated with a large gene list. Thus, a highly centralized and ready-to-use gene-annotation knowledgebase is in demand for high throughput gene functional analysis. The DAVID Knowledgebase is built around the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of gene/protein identifiers from a variety of public genomic resources into DAVID gene clusters. The grouping of such identifiers improves the cross-reference capability, particularly across NCBI and UniProt systems, enabling more than 40 publicly available functional annotation sources to be comprehensively integrated and centralized by the DAVID gene clusters. The simple, pair-wise, text format files which make up the DAVID Knowledgebase are freely downloadable for various data analysis uses. In addition, a well organized web interface allows users to query different types of heterogeneous annotations in a high-throughput manner. The DAVID Knowledgebase is designed to facilitate high throughput gene functional analysis. For a given gene list, it not only provides the quick accessibility to a wide range of heterogeneous annotation data in a centralized location, but also enriches the level of biological information for an individual gene. Moreover, the entire DAVID Knowledgebase is freely downloadable or searchable at .
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影响因子：
3
作者：
Alibés A;Yankilevich P;Cañada A;Díaz-Uriarte R
通讯作者：
Díaz-Uriarte R
影响因子：
14.9
作者：
Pruitt KD;Tatusova T;Maglott DR
通讯作者：
Maglott DR
影响因子：
14.9
作者：
Maglott D;Ostell J;Pruitt KD;Tatusova T
通讯作者：
Tatusova T
影响因子：
7
作者：
Kent, WJ;Hsu, F;Haussler, D
通讯作者：
Haussler, D
影响因子：
5.8
作者：
Beissbarth, T;Speed, TP
通讯作者：
Speed, TP