Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy
Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy
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白藜芦醇诱导人 K562 细胞凋亡、红系分化和自噬
DOI：
10.1007/s13277-014-1701-y
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Liu Jing
中科院分区：
文献类型：
--
作者：
Yan Hui-Wen;Hu Wei-Xin;Zhang Jie-Ying;Wang Ye;Xia Kun;Peng Min-Yuan;Liu Jing
白藜芦醇（RES）是一种天然存在的植物甲状腺素，在白血病细胞中具有凋亡和诱导全球作用，但是细胞中红细胞分化的潜在诱导尚未完全了解。在这里，我们研究了RES对人的影响
Resveratrol (Res) is a naturally occurring phytoalexin with apoptotic and inducing-glob effects in leukemic cells, but the potential induction of erythroid differentiation in cells is not fully understood. Here, we investigated the effects of Res on human erythro-megakaryoblastic leukemia cell line K562. Among the treated cells, proliferation was inhibited and the occurrence of cell apoptosis and cell death were detected. Erythroid differentiation assay was explored, and we found that Res could increase the expression of glycophorin A (GPA), HBA1, HBB, and γ-globin genes and enforced the expression of GPA, CD71, and Band3 proteins. Res also induced K562 cell autophagy when the concentration of Res was increased up to 50 or 100 μM. Our findings suggested that Res possesses the potency not only inducing apoptosis but also inducing erythroid differentiation and autophagy in K562 cells. These results provide that Res may be a therapeutic candidate for chronic myelogenous leukemia treatment.
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影响因子：
11.4
作者：
B. Clarkson;A. Strife
通讯作者：
B. Clarkson;A. Strife
影响因子：
6.5
作者：
Rodrigue, CM;Arous, N;Garel, MC
通讯作者：
Garel, MC
影响因子：
4.7
作者：
Nianzeng Xing;Yi Chen;Susan H. Mitchell;Charles Y. F. Young
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影响因子：
11.2
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Antonio Tabilio;P. Pelicci;G. Vinci;P. Mannoni;Curt I. Civin;W. Vainchenker;Ugo Testa;M. Lipiński-M
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Antonio Tabilio;P. Pelicci;G. Vinci;P. Mannoni;Curt I. Civin;W. Vainchenker;Ugo Testa;M. Lipiński-M
影响因子：
4.3
作者：
Hai-bo Zhou;Yun Yan;Yani Sun;Ju-ren Zhu
通讯作者：
Hai-bo Zhou;Yun Yan;Yani Sun;Ju-ren Zhu