Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.
Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease.
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DOI：
10.1038/srep02455
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发表时间：
2013
影响因子：
4.6
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
--
作者：
Kawai, Masataka;Ogawa, Yoko;Shimmura, Shigeto;Ohta, Shigeki;Suzuki, Takanori;Kawamura, Naoshi;Kuwana, Masataka;Kawakami, Yutaka;Tsubota, Kazuo
衰老通常被定义为随着年龄的增长，细胞和组织中各种有害变化的积累。为了探讨慢性移植物抗宿主病（cGVHD）模型小鼠泪腺的衰老变化，我们从cGVHD模型小鼠、未治疗的老年小鼠和青年小鼠中获取标本，并进行组织病理学和免疫印迹检查。氧化应激标志物8-OHdG、4-HNE和己酰损伤（HEL）以及其他衰老标志物p16和p38用于评估样本。慢性移植物抗宿主病和老年小鼠毛细血管内皮细胞和浸润的单个核细胞表达氧化应激标志物和其他衰老标志物，而青年小鼠则不表达。cGVHD小鼠的组织学变化和衰老标志物的表达表现出与衰老小鼠相似的特征。这些结果表明，通常随着年龄的增长而出现的变化在患有泪腺cGVHD的小鼠的生命中发生得更早。
Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the lacrimal glands of chronic graft-versus-host disease (cGVHD) model mice, we obtained the specimens from cGVHD model mice, untreated aged and young mice, and examined by histopathology, and immunoblotting. Oxidative stress markers, 8-OHdG, 4-HNE, and hexonoyl lesion (HEL), and other aging markers, p16 and p38, were used to assess the samples. The infiltrating mononuclear cells and endothelia of capillaries in the cGVHD and aged mice expressed the oxidative stress markers and other aging markers, but not in the young mice. Histological changes and the expression of aging markers in the samples from cGVHD mice exhibited similar features to those in aging mice. These results suggest that changes that typically appear with advanced age occur earlier in the lives of mice with lacrimal gland cGVHD.
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影响因子：
4.1
作者：
DAMATO, BE;ALLAN, D;LEE, WR
通讯作者：
LEE, WR
影响因子：
4.8
作者：
Jung, MS;Jin, DH;Shin, DY
通讯作者：
Shin, DY
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA
影响因子：
168.9
作者：
Ferrara, James L. M.;Levine, John E.;Reddy, Pavan;Holler, Ernst
通讯作者：
Holler, Ernst
DOI：
10.1007/978-1-60761-411-1_13
发表时间：
2010-01-01
期刊：
ADVANCED PROTOCOLS IN OXIDATIVE STRESS II
影响因子：
--
作者：
Jung, Tobias;Hoehn, Annika;Grune, Tilman
通讯作者：
Grune, Tilman