Antibiotic resistance shaping multi-level population biology of bacteria.
Antibiotic resistance shaping multi-level population biology of bacteria.
复制标题
DOI：
10.3389/fmicb.2013.00015
复制
发表时间：
2013
影响因子：
5.2
通讯作者：
Coque TM
中科院分区：
文献类型：
--
作者：
Baquero F;Tedim AP;Coque TM
抗生素具有天然功能，主要涉及细胞间信号网络。抗生素的人为生产及其在微生物圈中的释放导致这些网络的干扰，抗生素耐药性倾向于保持其完整性。这种适应的代价是抗生素耐药性基因以及这些基因所在的所有遗传和细胞载体的出现和传播。对不同进化单位（基因、整合子、转座子、质粒、细胞、群落和微生物组、宿主）组合的选择是高度不对称的。每个选择单元都是一个自利的实体，为了自己的利益而利用较高层次的单元，但在这样做的过程中，较高层次的单元可能会因为利用较低层次的单元而获得传播的关键特征。这种相互作用的权衡塑造了抗生素耐药性的群体生物学，这是一个由独立的“群体生物学”组成的复杂阵列。抗生素改变了这些单位的丰度和相互作用场。抗生素增加了“临床”抗生素耐药基因的数量和可进化性，但也可能增加了许多其他具有不同主要功能但在环境耐药基因组中具有耐药表型的基因。抗生素影响整合子、转座子和质粒的丰度、模块性和传播，主要作用于抗生素时代之前存在的结构。抗生素丰富了特定的细菌谱系和克隆，并有助于局部克隆化过程。抗生素放大了微生物组内共享抗生素抗性基因和平台的特定遗传交换社区。特别是在人类或动物宿主中，微生物组学组成可能促进参与抗生素耐药性的进化单位之间的相互作用。对抗生素耐药性的理解意味着扩大我们对细菌多层次群体生物学的认识。
Antibiotics have natural functions, mostly involving cell-to-cell signaling networks. The anthropogenic production of antibiotics, and its release in the microbiosphere results in a disturbance of these networks, antibiotic resistance tending to preserve its integrity. The cost of such adaptation is the emergence and dissemination of antibiotic resistance genes, and of all genetic and cellular vehicles in which these genes are located. Selection of the combinations of the different evolutionary units (genes, integrons, transposons, plasmids, cells, communities and microbiomes, hosts) is highly asymmetrical. Each unit of selection is a self-interested entity, exploiting the higher hierarchical unit for its own benefit, but in doing so the higher hierarchical unit might acquire critical traits for its spread because of the exploitation of the lower hierarchical unit. This interactive trade-off shapes the population biology of antibiotic resistance, a composed-complex array of the independent “population biologies.” Antibiotics modify the abundance and the interactive field of each of these units. Antibiotics increase the number and evolvability of “clinical” antibiotic resistance genes, but probably also many other genes with different primary functions but with a resistance phenotype present in the environmental resistome. Antibiotics influence the abundance, modularity, and spread of integrons, transposons, and plasmids, mostly acting on structures present before the antibiotic era. Antibiotics enrich particular bacterial lineages and clones and contribute to local clonalization processes. Antibiotics amplify particular genetic exchange communities sharing antibiotic resistance genes and platforms within microbiomes. In particular human or animal hosts, the microbiomic composition might facilitate the interactions between evolutionary units involved in antibiotic resistance. The understanding of antibiotic resistance implies expanding our knowledge on multi-level population biology of bacteria.
登录
查看更多内容
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3.2
作者：
Aubert, Daniel;Naas, Thierry;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
6.4
作者：
Allen HK;Looft T;Bayles DO;Humphrey S;Levine UY;Alt D;Stanton TB
通讯作者：
Stanton TB
影响因子：
4.9
作者：
Baquero, MR;Galán, JC;Baquero, F
通讯作者：
Baquero, F
影响因子：
5.2
作者：
Baquero, Fernando
通讯作者：
Baquero, Fernando