Dmrt genes in the development and evolution of sexual dimorphism.

Dmrt genes in the development and evolution of sexual dimorphism.
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DOI:
10.1016/j.tig.2012.02.002
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发表时间:
2012-04
期刊:
影响因子:
11.4
通讯作者:
Kopp, Artyom
Kopp, Artyom
中科院分区:
生物学1区
文献类型:
--
作者:
Kopp, Artyom

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大多数动物是两性异形的,但不同的类群有不同的性别特异性特征。尽管动物谱系之间在性发育的遗传控制方面存在重大差异,但转录因子Dmrt家族已被证明参与迄今为止研究的所有动物的性别特异性分化。近年来,Dmrt基因的功能已在许多动物群体中得到表征,为广泛的比较视角开辟了道路。在这篇综述中,我专注于Dmrt基因在整个动物王国的功能的相似性和差异。我强调了一些共同的主题,在不同类群的性发育,讨论如何Dmrt基因在动物进化过程中获得了新的角色,并显示它们如何有助于新的性别特异性特征的起源。
Most animals are sexually dimorphic, yet different taxa have different sex-specific traits. Despite major differences in the genetic control of sexual development among animal lineages, the Dmrt family of transcription factors has been shown to be involved in sex-specific differentiation in all animals studied so far. In recent years, the functions of Dmrt genes have been characterized in many animal groups, opening the way for a broad comparative perspective. In this review, I focus on the similarities and differences in the functions of Dmrt genes across the animal kingdom. I highlight a number of common themes in the sexual development of different taxa, discuss how Dmrt genes have acquired new roles during animal evolution, and show how they contributed to the origin of novel sex-specific traits.
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