Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning.
Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning.
复制标题
DOI：
10.1016/j.neuron.2017.09.040
复制
发表时间：
2017-10-11
期刊：
影响因子：
16.2
通讯作者：
Lovinger DM
中科院分区：
文献类型：
--
作者：
Kupferschmidt DA;Juczewski K;Cui G;Johnson KA;Lovinger DM
Changes in cortical and striatal function underlie the transition from novel actions to refined motor skills. How discrete, anatomically defined corticostriatal projections function in vivo to encode skill learning remains unclear. Using novel fiber photometry approaches to assess real-time activity of associative inputs from medial prefrontal cortex to dorsomedial striatum and sensorimotor inputs from motor cortex to dorsolateral striatum, we show that associative and sensorimotor inputs co-engage early in action learning, and disengage in a dissociable manner as actions are refined. Disengagement of associative, but not sensorimotor, inputs predicts individual differences in subsequent skill learning. Divergent somatic and presynaptic engagement in both projections during early action learning suggests potential learning-related in vivo modulation of presynaptic corticostriatal function. These findings reveal parallel processing within associative and sensorimotor circuits that challenges and refines existing views of corticostriatal function, and expose neuronal projection- and compartment-specific activity dynamics that encode and predict action learning.
登录
查看更多内容
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
影响因子：
2.5
作者：
Jueptner, M;Stephan, KM;Passingham, RE
通讯作者：
Passingham, RE
影响因子：
2.5
作者：
Floyer-Lea, A;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
16.2
作者：
Cao VY;Ye Y;Mastwal S;Ren M;Coon M;Liu Q;Costa RM;Wang KH
通讯作者：
Wang KH
影响因子：
25
作者：
Bassett DS;Yang M;Wymbs NF;Grafton ST
通讯作者：
Grafton ST