Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.
Array-based sensing of normal, cancerous, and metastatic cells using conjugated fluorescent polymers.
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DOI:
10.1021/ja9061272
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发表时间:
2010-01-27
影响因子:
15
通讯作者:
Rotello, Vincent M.
中科院分区:
文献类型:
--
作者:
Bajaj, Avinash;Miranda, Oscar R.;Phillips, Ronnie;Kim, Ik-Bum;Jerry, D. Joseph;Bunz, Uwe H. F.;Rotello, Vincent M.
A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface characteristics. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of cell type as well differentiating between normal, cancerous and metastatic isogenic cell types with high accuracy.
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