Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features.
Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features.
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COVID-19 和 H1N1 感染患者肠道菌群的变化及其与临床特征的关联
DOI：
10.1038/s42003-021-02036-x
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发表时间：
2021-04-13
影响因子：
5.9
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Lv L;Gu S;Jiang H;Yan R;Chen Y;Chen Y;Luo R;Huang C;Lu H;Zheng B;Zhang H;Xia J;Tang L;Sheng G;Li L
肠道微生物与COVID-19或H1N1感染之间的关系尚未完全了解。在这里，我们使用内部转录间隔区（ITS）3-ITS 4测序比较了67名COVID-19患者，35名H1N1感染患者和48名健康对照（HC）的肠道菌群，并分析了它们与临床特征和细菌微生物群的相关性。与HC相比，真菌负荷更高。在COVID-19和H1N1感染的患者中，真菌菌群生态失调的主要特征是真菌（如假丝酵母菌和青霉菌）的消耗，但包括光滑念珠菌在内的几种真菌在H1N1感染的患者中富集。具有轻度和重度症状的COVID-19患者的肠道菌群特征相似。住院治疗没有明显的额外影响。在COVID-19患者中，毛霉菌门与梭菌正相关，黑曲霉与腹泻正相关，桔青霉与C反应蛋白（CRP）负相关。甲型H1N1流感病毒感染者中，类青霉曲霉菌与毛螺菌科成员呈正相关，毛霉菌与CRP呈正相关，毛霉菌与降钙素原呈负相关。因此，肠道菌群失调在COVID-19患者和H1N1感染患者中均会发生，并且直到患者出院且不再需要医疗护理时才会改善。
The relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the gut mycobiota of 67 COVID-19 patients, 35 H1N1-infected patients and 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing and analysed their associations with clinical features and the bacterial microbiota. Compared to HCs, the fungal burden was higher. Fungal mycobiota dysbiosis in both COVID-19 and H1N1-infected patients was mainly characterized by the depletion of fungi such asAspergillusandPenicillium, but several fungi, includingCandida glabrata, were enriched in H1N1-infected patients. The gut mycobiota profiles in COVID-19 patients with mild and severe symptoms were similar. Hospitalization had no apparent additional effects. In COVID-19 patients, Mucoromycota was positively correlated withFusicatenibacter,Aspergillus nigerwas positively correlated with diarrhoea, andPenicillium citrinumwas negatively correlated with C-reactive protein (CRP). In H1N1-infected patients,Aspergillus penicilloideswas positively correlated with Lachnospiraceae members,Aspergilluswas positively correlated with CRP, and Mucoromycota was negatively correlated with procalcitonin. Therefore, gut mycobiota dysbiosis occurs in both COVID-19 patients and H1N1-infected patients and does not improve until the patients are discharged and no longer require medical attention.
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ACE2将氨基酸营养不良与微生物生态学和肠炎联系起来。
影响因子：
64.8
作者：
Hashimoto T;Perlot T;Rehman A;Trichereau J;Ishiguro H;Paolino M;Sigl V;Hanada T;Hanada R;Lipinski S;Wild B;Camargo SM;Singer D;Richter A;Kuba K;Fukamizu A;Schreiber S;Clevers H;Verrey F;Rosenstiel P;Penninger JM
通讯作者：
Penninger JM
DOI：
10.1016/j.diagmicrobio.2010.04.005
发表时间：
2011-08-01
影响因子：
2.9
作者：
Chen, Yu;Chen, Zhenjing;Li, Lanjuan
通讯作者：
Li, Lanjuan
影响因子：
3.2
作者：
de Assuncao, Thiago Milech;Batista, Eraldo L., Jr.;Santos, Diogenes Santiago
通讯作者：
Santos, Diogenes Santiago
影响因子：
9.6
作者：
Azoulay, E;Timsit, JF;Schlemmer, B
通讯作者：
Schlemmer, B
影响因子：
8
作者：
Liguori, Giuseppina;Lamas, Bruno;Sokol, Harry
通讯作者：
Sokol, Harry