Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.
Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.
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DOI：
10.3390/nu13030899
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发表时间：
2021-03-10
期刊：
影响因子：
5.9
通讯作者：
Nakamura K
中科院分区：
文献类型：
--
作者：
Nakano H;Hashimoto H;Mochizuki M;Naraba H;Takahashi Y;Sonoo T;Matsuishi Y;Ogawa Y;Shimojo N;Inoue Y;Nakamura K
尚未确定β-羟基-β-甲基丁酸（HMB）复合物给药的效果和肌联蛋白（肌肉损伤的生物标志物）在老年轻微创伤患者急性期的意义。在这项单中心、随机对照研究中，纳入了年龄≥ 70岁且损伤严重程度评分< 16的创伤患者。测量第1天和第3天的肌联蛋白值，干预组接受HMB复合物（2.4 g HMB + 14 g谷氨酰胺+ 14 g精氨酸），对照组接受谷氨酰胺复合物（7.2 g蛋白质，包括6 g谷氨酰胺）。在康复治疗的第一天和2周后，对超声检查的股直肌横截面积（RFCSA）、握力和Barthel指数进行评估。我们分析了24名HMB和25名对照参与者。第3天的Titin值与随访时的握力（r =-0.34，p = 0.03）和Barthel指数（r =-0.39，p = 0.01）相关。在随访时，HMB复合物补充对RFCSA（2.41 vs. 2.45 cm 2，p = 0.887）、握力（13.3 vs. 13.1 kg，p = 0.946）或Barthel指数（20.0 vs. 50.0，p = 0.404）没有影响。Titin值可能与随后的身体功能有关。从急性期开始短期补充HMB复合物并不能改善肌肉损伤。
The effects of beta-hydroxy-beta-methylbutyrate (HMB) complex administration and the significance of titin, a biomarker of muscle injury, in elderly minor trauma patients in acute phase has not been established. In this single-center, randomized controlled study, trauma patients aged ≥ 70 years with an injury severity score < 16 were included. Titin values on days 1 and 3 were measured and the intervention group received HMB complex (2.4 g of HMB + 14 g of glutamine + 14 g of arginine) and the control group received glutamine complex (7.2 g of protein including 6 g of glutamine). The cross-sectional area of the rectus femoris (RFCSA) on ultrasound, grip strength, and the Barthel Index were assessed on the first day of rehabilitation and after 2 weeks. We analyzed 24 HMB and 25 control participants. Titin values on day 3 correlated with grip strength (r = −0.34, p = 0.03) and the Barthel Index (r = −0.39, p = 0.01) at follow-up. HMB complex supplementation had no effect on the RFCSA (2.41 vs. 2.45 cm2, p = 0.887), grip strength (13.3 vs. 13.1 kg, p = 0.946), or the Barthel Index (20.0 vs. 50.0, p = 0.404) at follow-up. Titin values might associate with subsequent physical function. Short-term HMB complex supplementation from acute phase did not ameliorate muscle injury.
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DOI：
10.1113/jp275444
发表时间：
2019-03
期刊：
The Journal of physiology
影响因子：
--
作者：
Crossland H;Skirrow S;Puthucheary ZA;Constantin-Teodosiu D;Greenhaff PL
通讯作者：
Greenhaff PL
影响因子：
3.4
作者：
Nakamura, Kensuke;Kihata, Atsushi;Morimura, Naoto
通讯作者：
Morimura, Naoto
DOI：
10.1093/gerona/glu103
发表时间：
2015-01-01
影响因子：
5.1
作者：
Moore, Daniel R.;Churchward-Venne, Tyler A.;Phillips, Stuart M.
通讯作者：
Phillips, Stuart M.
影响因子：
3.4
作者：
Baier, Shawn;Johannsen, Darcy;Flakoll, Paul
通讯作者：
Flakoll, Paul
影响因子：
6.3
作者：
Deutz, Nicolaas E. P.;Pereira, Suzette L.;Wolfe, Robert R.
通讯作者：
Wolfe, Robert R.