Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.
Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.
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以严重缺血后收缩功能障碍为特征的顿挫心肌中铊 201 动力学。
DOI：
10.1161/01.cir.81.5.1622
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发表时间：
1990
期刊：
影响因子：
37.8
通讯作者：
Beller,GA
中科院分区：
文献类型：
--
作者：
Moore,CA;Cannon,J;Watson,DD;Kaul,S;Beller,GA
本研究测试的假设是，尽管存在严重的缺血后心肌功能障碍（“震惊”），但只要避免不可逆的肌膜损伤，就应保留铊 201 的提取和随后的细胞内冲洗。为了产生心肌顿抑，19只患有严重左前降支冠状动脉（LAD）狭窄的开胸狗接受了10次5分钟的完全LAD闭塞，每次期间通过通过严重狭窄的回流进行了10分钟的再灌注。在同一时间段观察的另外 12 只对照狗中，在放置临界狭窄后没有进行 LAD 闭塞。连续测量血流动力学、定量二维超声心动图的局部心肌增厚以及微球测定的局部血流量。在 18 只被击晕的狗中，第 10 个再灌注期后 40 分钟时，LAD 区的收缩期增厚显着降低至 0.4 +/- 2.4%，而在匹配时间，12 只对照狗的收缩期增厚为 32.5 +/- 2.2%（p 小于 0.001）。在第 10 次回流后，在由 13 只致昏狗 (0.78) 和 6 只对照狗 (0.79) 组成的亚组中，使用冠状动脉内 201Tl 给药的双同位素方法测定的 201Tl 首过提取分数具有可比性。在另一组六只致昏狗（60+/-13分钟）和六只对照狗（53+/-14分钟）中，细胞内清除率的T1/2也没有显着差异，最初分布在间质室中的201Tl剂量的百分比也没有显着差异（11+/-3%对7+/-2%）。第 10 次复流后 40 分钟时，两组的全身血流动力学和局部血流量相当。通过氯化三苯基四唑染色，没有狗有心肌坏死的证据。因此，在由重复短暂的LAD闭塞产生的严重缺血后功能障碍（震惊）的犬模型中观察到正常的心肌201T1提取和冲刷动力学。这些发现可能对应用静息 201Tl 闪烁扫描法评估冠状动脉疾病和最终可逆的局部心肌不协同的患者的灌注和活力具有重要的临床意义。
The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-chested dogs with a critical left anterior descending coronary artery (LAD) stenosis underwent 10 5-minute periods of total LAD occlusion, each interspersed by 10 minutes of reperfusion by reflow through the critical stenosis. In another 12 control dogs observed for the same time period, no LAD occlusions were performed after placement of the critical stenosis. Hemodynamics, regional myocardial thickening by quantitative two-dimensional echocardiography, and microsphere-determined regional blood flows were serially measured. In 18 stunned dogs, systolic thickening in the LAD zone was markedly reduced to 0.4 +/- 2.4% at 40 minutes after the 10th reperfusion period compared with 32.5 +/- 2.2% thickening (p less than 0.001) in 12 control dogs at a matched time. The 201Tl first-pass extraction fraction determined by a double-isotope method using intracoronary 201Tl administration was comparable after the 10th reflow in a subgroup of 13 stunned (0.78) and six control (0.79) dogs. The T1/2 for the intracellular washout rate was also not significantly different in another group of six stunned (60 +/- 13 minutes) and six control (53 +/- 14 minutes) dogs, nor was the percentage of the 201Tl dose initially distributed in the interstitial compartment (11 +/- 3% vs. 7 +/- 2%). Systemic hemodynamics and regional flows were comparable in the two groups at 40 minutes after the 10th reflow. No dog had evidence of myocardial necrosis by triphenyl tetrazolium chloride staining. Thus, normal myocardial 201Tl extraction and washout kinetics are observed in a canine model of severe postischemic dysfunction (stunning) produced by repetitive brief LAD occlusions. These findings might have important clinical implications concerning the application of rest 201Tl scintigraphy for evaluation of perfusion and viability in patients with coronary artery disease and regional myocardial asynergy that is ultimately reversible.
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DOI：
--
发表时间：
1967
期刊：
The Journal of General Physiology
影响因子：
--
作者：
J. Holloszy;H. Narahara
通讯作者：
H. Narahara
DOI：
10.1152/ajplegacy.1962.202.3.440
发表时间：
1962
期刊：
The American journal of physiology
影响因子：
--
作者：
H. Lorković
通讯作者：
H. Lorković
钒酸钠对脂肪细胞葡萄糖转运的胰岛素样作用是在胰岛素受体后水平介导的。
DOI：
10.1042/bj2380663
发表时间：
1986
期刊：
The Biochemical journal
影响因子：
--
作者：
Green,A
通讯作者：
Green,A
大鼠比目鱼肌的葡萄糖摄取：急性卸载和随后重新加载的影响。
影响因子：
3.3
作者：
Eric J. Henriksen;Marc E. Tischler
通讯作者：
Marc E. Tischler
影响因子：
3.3
作者：
WALLBERGHENRIKSSON, H;CONSTABLE, SH;HOLLOSZY, JO
通讯作者：
HOLLOSZY, JO