Evaluation of segmented 3D acquisition schemes for whole-brain high-resolution arterial spin labeling at 3 T.
Evaluation of segmented 3D acquisition schemes for whole-brain high-resolution arterial spin labeling at 3 T.
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DOI：
10.1002/nbm.3201
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发表时间：
2014-11
影响因子：
2.9
通讯作者：
Fernandez-Seara, Maria A.
中科院分区：
文献类型：
--
作者：
Vidorreta, Marta;Balteau, Evelyne;Wang, Ze;De Vita, Enrico;Pastor, Maria A.;Thomas, David L.;Detre, John A.;Fernandez-Seara, Maria A.
关键词：
最近的技术发展显着提高了动脉自旋标记（ASL）灌注MRI的SNR。尽管如此，典型的ASL采集仍然采用大的体素尺寸。本工作的目的是实施和评价两个ASL序列优化全脑高分辨率灌注成像，结合伪连续ASL（pCASL），背景抑制（BS）和3D分段读出，不同的平面内k空间轨迹。对两个序列实施相同的标记和BS脉冲。比较了具有不同平面内轨迹的两种分段3D读出方案：笛卡尔（3D GRASE）和螺旋（3D RARE Stack-Of-Spirals）。15名健康志愿者在3 T条件下用两种ASL序列获得高分辨率灌注图像（2×2×4 mm 3）。根据SNR和灰-白色物质对比度评价灌注图的质量。点扩散函数模拟进行了评估的有效分辨率上的读出差异的影响。pCASL、平面内分段3D读数和BS的组合提供了全脑的高SNR、高分辨率的ASL灌注图像。尽管两种序列都产生了出色的图像质量，但3D RARE Stack-Of-Spirals读出产生的时间和空间SNR高于3D GRASE（空间信噪比分别为8.5 ± 2.8和3.7 ± 1.4;时间SNR分别为27.4 ± 12.5和15.6 ± 7.6），以及由于其对中心k空间区域的固有过采样而导致的通过平面的模糊减少，其降低的有效TE和更短的总读出时间，以有效平面内体素尺寸的略微增加为代价。
Recent technical developments have significantly increased the SNR of arterial spin labeled (ASL) perfusion MRI. Despite this, typical ASL acquisitions still employ large voxel sizes. The purpose of this work was to implement and evaluate two ASL sequences optimized for whole-brain high-resolution perfusion imaging, combining pseudo-continuous ASL (pCASL), background suppression (BS) and 3D segmented readouts, with different in-plane k-space trajectories. Identical labeling and BS pulses were implemented for both sequences. Two segmented 3D readout schemes with different in-plane trajectories were compared: Cartesian (3D GRASE), and spiral (3D RARE Stack-Of-Spirals). High-resolution perfusion images (2×2×4 mm3) were acquired in fifteen young healthy volunteers with the two ASL sequences at 3T. The quality of the perfusion maps was evaluated in terms of SNR and gray-to-white matter contrast. Point-spread-function simulations were carried out to assess the impact of readout differences on the effective resolution. The combination of pCASL, in-plane segmented 3D readouts and BS provided high-SNR high-resolution ASL perfusion images of the whole brain. Although both sequences produced excellent image quality, the 3D RARE Stack-Of-Spirals readout yielded higher temporal and spatial SNR than 3D GRASE (Spatial SNR = 8.5 ± 2.8 and 3.7 ± 1.4; Temporal SNR = 27.4 ± 12.5 and 15.6 ± 7.6, respectively) and decreased through-plane blurring due to its inherent oversampling of the central k-space region, its reduced effective TE and shorter total readout time, at the expense of a slight increase in the effective in-plane voxel size.
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影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
JONES, T
影响因子：
5.7
作者：
Glover, Gary H.
通讯作者：
Glover, Gary H.
影响因子：
3.3
作者：
Man, LC;Pauly, JM;Macovski, A
通讯作者：
Macovski, A
影响因子：
10.6
作者：
NOLL, DC;MEYER, CH;MACOVSKI, A
通讯作者：
MACOVSKI, A
影响因子：
10.6
作者：
JACKSON, JI;MEYER, CH;MACOVSKI, A
通讯作者：
MACOVSKI, A