Air Pollution, housing and respirfatory tract Infections in Children: NatIonal birth Cohort study (PICNIC): study protocol.
Air Pollution, housing and respirfatory tract Infections in Children: NatIonal birth Cohort study (PICNIC): study protocol.
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DOI：
10.1136/bmjopen-2020-048038
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发表时间：
2021-05-03
期刊：
影响因子：
2.9
通讯作者：
Hardelid P
中科院分区：
文献类型：
--
作者：
Favarato G;Clemens T;Cunningham S;Dibben C;Macfarlane A;Milojevic A;Taylor J;Wijlaars LPMM;Wood R;Hardelid P
呼吸道感染 (RTI) 是英国 5 岁以下儿童入院的最常见原因。环境空气污染暴露和不利的居住条件对幼儿 RTI 入院的相对影响尚不清楚，并且尚未在英国进行评估。 PICNIC 研究（儿童空气污染、住房和呼吸道感染：全国出生队列研究）的目的是量化子宫内、婴儿和儿童时期暴露于环境空气污染和不良住房条件与 5 岁以下儿童 RTI 入院风险的相关程度。我们将使用国家出生队列管理数据，包括 2005 年至 2014 年在英格兰出生的所有儿童以及 1997 年至 2020 年在苏格兰出生的所有儿童的数据，这些数据是通过民事登记、生育和入院数据集之间的链接创建的。我们将通过与住房条件和社会经济地位的人口普查数据以及环境空气污染和建筑特征的小区域数据相联系，进一步增强这些群体。我们将使用事件时间分析来检查空气污染、住房特征和儿童 RTI 入院风险之间的关联，计算环境空气污染和住房特征的人口归因分数，并使用因果中介分析来探索住房和空气污染影响婴儿 RTI 入院风险的机制。迄今为止，我们已获得英格兰六个道德和信息治理委员会和苏格兰两个委员会的批准。我们的研究结果将告知家长、国家和地方政府、国家医疗服务体系和志愿部门组织不良住房条件和空气污染对幼儿 RTI 入院的相对影响。我们将在开放获取期刊上发表我们的结果，并通过家长团体、社交媒体以及 PICNIC 网站向公众展示我们的结果。代码和元数据将发布在 GitHub 上。
Respiratory tract infections (RTIs) are the most common reason for hospital admission among children <5 years in the UK. The relative contribution of ambient air pollution exposure and adverse housing conditions to RTI admissions in young children is unclear and has not been assessed in a UK context. The aim of the PICNIC study (Air Pollution, housing and respiratory tract Infections in Children: NatIonal birth Cohort Study) is to quantify the extent to which in-utero, infant and childhood exposures to ambient air pollution and adverse housing conditions are associated with risk of RTI admissions in children <5 years old. We will use national administrative data birth cohorts, including data from all children born in England in 2005–2014 and in Scotland in 1997–2020, created via linkage between civil registration, maternity and hospital admission data sets. We will further enhance these cohorts via linkage to census data on housing conditions and socioeconomic position and small area-level data on ambient air pollution and building characteristics. We will use time-to-event analyses to examine the association between air pollution, housing characteristics and the risk of RTI admissions in children, calculate population attributable fractions for ambient air pollution and housing characteristics, and use causal mediation analyses to explore the mechanisms through which housing and air pollution influence the risk of infant RTI admission. To date, we have obtained approval from six ethics and information governance committees in England and two in Scotland. Our results will inform parents, national and local governments, the National Health Service and voluntary sector organisations of the relative contribution of adverse housing conditions and air pollution to RTI admissions in young children. We will publish our results in open-access journals and present our results to the public via parent groups and social media and on the PICNIC website. Code and metadata will be published on GitHub.
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影响因子：
2.9
作者：
Coathup V;Macfarlane A;Quigley M
通讯作者：
Quigley M
影响因子：
8.3
作者：
Dibben C;Clemens T
通讯作者：
Clemens T
DOI：
10.1080/09603120500397680
发表时间：
2006-02-01
影响因子：
3.2
作者：
Hinwood, AL;De Klerk, N;Spickett, J
通讯作者：
Spickett, J
影响因子：
6.3
作者：
Lewis, Kate;De Stavola, Bianca;Hardelid, Pia
通讯作者：
Hardelid, Pia
影响因子：
24.3
作者：
Hardelid, Pia;Verfuerden, Maximiliane;Gilbert, Ruth
通讯作者：
Gilbert, Ruth