Long-term intra- and inter-individual biological variation of serum lipid of HIV-infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study (MACS).
Long-term intra- and inter-individual biological variation of serum lipid of HIV-infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study (MACS).
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DOI：
10.1186/s12944-022-01668-0
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发表时间：
2022-07-27
影响因子：
4.5
通讯作者：
Detels, Roger
中科院分区：
文献类型：
--
作者：
Aziz, Najib;Gjertson, David W.;Mimiaga, Matthew J.;Azarkman, Chantel D.;Soto, Rey;Alexopoulos, Nicole;Detels, Roger
评估HIV-1感染者和未感染者体内和个体间的长期生物学变异系数（CVI）、衰老和降胆固醇药物对血脂水平的影响。在17年中，每6个月对140名未感染HIV的人的血液进行总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）分析。（38-66岁）和90名接受艾滋病毒治疗的感染者（48-64岁）白色高加索男性，检查CVI、CVG和降胆固醇药物（CLD）对脂质水平的影响，以及生物标志物每年的估计变化。除HDL-C外，在HIV-1感染和未感染的未服用CLD的男性中，长期CVI与CVG相比血清TC、TG和LDL-C水平更高。排除HIV阳性男性的TG结果，两组未服用CLD的血清TC、HDL-C和LDL-C水平的CVI均低于CVG。在77名HIV阴性男性服用CLD和63名未服用CLD之间，脂质生物标志物的中位血清值存在显著差异（p < 0.05）。此外，除HDL外，28名服用或未服用CLD的HIV阳性男性的TC、TG和LDL-C的中位数存在显著差异（p < 0.05）。长期CVI和CVG的生物标志物将有助于监测抗病毒治疗对HIV感染者血脂谱的副作用。HIV感染者的胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白的CVI均显著高于非HIV感染者。有趣的是，与未接受CLD的男性相比，接受CLD的男性的长期CVI高于CVG。长期模式的CVI和CVG的脂质标志物在艾滋病毒感染和未感染的男性CLDs从他们的短期模式不同。
To assess the long-term biological coefficient of variation within individuals (CVI) and between individuals (CVG), effect of aging and cholesterol lowering drugs on blood levels of lipids in HIV-1-infected and -uninfected men. Bloods were analyzed every six months over 17 years for total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in 140 HIV-uninfected (38–66 years old) and 90 HIV-treated infected (48–64 years old) white Caucasian men to examine CVI, CVG, and the effect of cholesterol lowering drugs (CLDs) on lipid levels, and estimated changes per year of biomarkers. With exception of HDL-C, the long term CVI compared with CVG were higher for serum levels of TC, TGs, and LDL-C in both HIV-1 infected and uninfected men not taking CLDs. Excluding results of TGs in HIV positive men, the CVI compared with CVG were lower for serum levels of TC, HDL-C, and LDL-C in both groups not taking CLDs. There were significant (p < 0.05) differences in the median serum values of lipid biomarkers among 77 HIV negative men taking and 63 not taking CLDs. Also, with exception of HDL, there were significant (p < 0.05) differences in the median values of TC, TGs and LDL-C among 28 HIV positive men taking or not taking CLDs. Long term CVI and CVG of biomarkers will be useful for monitoring antiviral therapy side effects on lipid profiles in HIV-infected men. CVI of HIV-infected men for TC, TGs, HDL, LDL were higher significantly than CVI of HIV-uninfected men. Interestingly the long term CVI were higher than CVG for the men, who were on CLDs compared to men not on CLDs. The long-term pattern of CVI and CVG of lipid markers in both HIV-infected and uninfected men on CLDs differed from their short-term pattern.
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