Uterine Microbiota: Residents, Tourists, or Invaders?
Uterine Microbiota: Residents, Tourists, or Invaders?
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DOI：
10.3389/fimmu.2018.00208
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发表时间：
2018
影响因子：
7.3
通讯作者：
Herbst-Kralovetz MM
中科院分区：
文献类型：
--
作者：
Baker JM;Chase DM;Herbst-Kralovetz MM
子宫微生物群已在各种条件和人群中报道;然而，尚不确定这些细菌是维持体内平衡的居民，容易被消除的游客或导致人类疾病的入侵者的水平。本文提供了一个历史的时间轴，并总结了这一主题的现状，旨在促进研究的优先事项和讨论这一有争议的话题。目前关于子宫微生物群的报告存在分歧，并进行了严格的审查和检查。建立和假定的途径细菌播种的人子宫和相互作用与远端粘膜网站进行了讨论。根据目前的文献，我们强调需要在这一领域进行额外的稳健的临床和转化研究。此外，我们还讨论了研究宿主-微生物群相互作用的必要性，以及这些微生物群对局部子宫内膜微环境的生理和功能影响，因为这些机制可能会影响不良的生殖、产科和妇科健康结局和后遗症。
Uterine microbiota have been reported under various conditions and populations; however, it is uncertain the level to which these bacteria are residents that maintain homeostasis, tourists that are readily eliminated or invaders that contribute to human disease. This review provides a historical timeline and summarizes the current status of this topic with the aim of promoting research priorities and discussion on this controversial topic. Discrepancies exist in current reports of uterine microbiota and are critically reviewed and examined. Established and putative routes of bacterial seeding of the human uterus and interactions with distal mucosal sites are discussed. Based upon the current literature, we highlight the need for additional robust clinical and translational studies in this area. In addition, we discuss the necessity for investigating host–microbiota interactions and the physiologic and functional impact of these microbiota on the local endometrial microenvironment as these mechanisms may influence poor reproductive, obstetric, and gynecologic health outcomes and sequelae.
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影响因子：
4.4
作者：
Fettweis JM;Serrano MG;Sheth NU;Mayer CM;Glascock AL;Brooks JP;Jefferson KK;Vaginal Microbiome Consortium (additional members);Buck GA
通讯作者：
Buck GA
影响因子：
2.8
作者：
Fettweis, Jennifer M.;Brooks, J. Paul;Buck, Gregory A.
通讯作者：
Buck, Gregory A.
DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.
影响因子：
6.1
作者：
Bailey, MT;Coe, CL
通讯作者：
Coe, CL
影响因子：
3.1
作者：
Franasiak, J. M.;Werner, M. D.;Scott, R. T.
通讯作者：
Scott, R. T.