Regulatory T cells in allergic diseases.
Regulatory T cells in allergic diseases.
复制标题
DOI：
10.1016/j.jaci.2016.06.003
复制
发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Chatila TA
中科院分区：
文献类型：
--
作者：
Noval Rivas M;Chatila TA
过敏性疾病的发病机制涉及对过敏原无效的耐受性免疫反应。调节性T细胞（TReg）细胞在维持对过敏原的免疫耐受中发挥关键作用，但TReg细胞在过敏性疾病中无法维持耐受性的机制尚不清楚。我们回顾了目前关于TReg细胞如何调节过敏原触发的免疫反应的不同成分以促进和维持耐受性的概念和建立的机制。我们还将讨论强调TReg细胞在过敏性疾病中的“双重”功能的最新进展：TReg细胞如何在促进对过敏原的耐受性中发挥重要作用，以及促过敏的炎症环境如何使TReg细胞向致病表型倾斜，从而加重和延续疾病。这些进展突出了新的治疗策略的机会，旨在通过促进TReg细胞和稳定性功能来重建慢性过敏性疾病的耐受性。
The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response towards allergens. Regulatory T cells (TReg) cells play a key role in sustaining immune tolerance to allergens, yet mechanisms by which TReg cells fail to maintain tolerance in allergic diseases are not well understood. We review current concepts and established mechanisms regarding how TReg cells regulate different components of allergen-triggered immune responses to promote and maintain tolerance. We will also discuss more recent advances that emphasize the “dual” functionality of TReg cells in allergic diseases: how TReg cells are essential in promoting tolerance to allergens but also how a pro-allergic inflammatory environment can skew TReg cells towards a pathogenic phenotype that aggravates and perpetuates disease. These advances highlight opportunities for novel therapeutic strategies that aim to re-establish tolerance in chronic allergic diseases by promoting TReg cell and stability function.
登录
查看更多内容
影响因子：
30.5
作者：
Charbonnier LM;Wang S;Georgiev P;Sefik E;Chatila TA
通讯作者：
Chatila TA
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
30.5
作者：
Burzyn D;Benoist C;Mathis D
通讯作者：
Mathis D
影响因子：
4.4
作者：
Bashir, MEH;Louie, S;Nagler-Anderson, C
通讯作者：
Nagler-Anderson, C